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Titolo:
DOES NITRIC-OXIDE MEDIATE CIRCULATORY FAILURE INDUCED BY 35-GHZ MICROWAVE-HEATING
Autore:
RYAN KL; FREI MR; BERGER RE; JAUCHEM JR;
Indirizzi:
TRINITY UNIV,DEPT BIOL SAN ANTONIO TX 78212 OPERAT TECHNOL CORP SAN ANTONIO TX 78229 USAF,ARMSTRONG LAB,RADIOFREQUENCY RADIAT DIV BROOKS AFB TX 78235
Titolo Testata:
Shock
fascicolo: 1, volume: 6, anno: 1996,
pagine: 71 - 76
SICI:
1073-2322(1996)6:1<71:DNMCFI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-L-ARGININE; BLOOD-PRESSURE; VASOCONSTRICTOR AGENTS; HEMORRHAGIC-SHOCK; RATS; SYNTHASE; HYPOTENSION; INHIBITION; HYPOREACTIVITY; HYPERTHERMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
K.L. Ryan et al., "DOES NITRIC-OXIDE MEDIATE CIRCULATORY FAILURE INDUCED BY 35-GHZ MICROWAVE-HEATING", Shock, 6(1), 1996, pp. 71-76

Abstract

The purpose of this study was to determine whether nitric oxide (NO) contributes to the hypotensive state induced by exposure to radiofrequency radiation of millimeter-wavelength (MMW). This was accomplished using a synthetic analogue of L-arginine, N-omega-nitro-L-arginine methyl ester (L-NAME), to competitively inhibit NO synthesis. Ketamine-anesthetized rats were instrumented for the measurement of arterial bloodpressure, EGG, and temperature at five sites. Animals were exposed to35-GHz radiofrequency radiation until mean arterial pressure (MAP) decreased to 75 mmHg. MMW exposure was then halted and either saline or L-NAME (1, 2.5, 5, or 10 mg/kg) was administered; each rat received only one dose. Following irradiation, L-NAME at each dose produced a peak increase in MAP that was smaller than that produced by the same doseof L-NAME in nonirradiated rats. There was no difference in post-MMW survival times between L-NAME- and saline-treated rats. These results indicate that bolus administration of L-NAME does not reverse hypotension induced by 35-GHz microwave heating, suggesting that excess levelsof NO do not mediate this form of circulatory failure.

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Documento generato il 18/09/20 alle ore 20:10:25