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Titolo:
ORAL ESTROGEN-TREATMENT INDUCES A DECREASE IN EXPRESSION OF SIALYL-LEWIS-X ON ALPHA(1)-ACID GLYCOPROTEIN IN FEMALES AND MALE-TO-FEMALE TRANSSEXUALS
Autore:
BRINKMANVANDERLINDEN ECM; HAVENAAR EC; VANOMMEN ECR; VANKAMP GJ; GOOREN LJG; VANDIJK W;
Indirizzi:
VAN DER BOECHORSTST 7 NL-1081 BT AMSTERDAM NETHERLANDS FREE UNIV AMSTERDAM,FAC MED,DEPT MED CHEM NL-1081 BT AMSTERDAM NETHERLANDS FREE UNIV AMSTERDAM HOSP,DEPT ENDOCRINOL AMSTERDAM NETHERLANDS FREE UNIV AMSTERDAM HOSP,DEPT CLIN CHEM AMSTERDAM NETHERLANDS
Titolo Testata:
Glycobiology
fascicolo: 4, volume: 6, anno: 1996,
pagine: 407 - 412
SICI:
0959-6658(1996)6:4<407:OEIADI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN ALPHA-1-ACID GLYCOPROTEIN; CROSSED IMMUNO-AFFINOELECTROPHORESIS; ACUTE-PHASE RESPONSE; RHEUMATOID-ARTHRITIS; TETRAANTENNARY GLYCANS; INTERCURRENT INFECTION; CARBOHYDRATE UNITS; CONCANAVALIN-A; INTERLEUKIN-1; MICROHETEROGENEITY;
Keywords:
CONTRACEPTIVES ORAL; ESTROGENS; FUCOSYLATION; OROSOMUCOID; SIALYL LEWIS X;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
E.C.M. Brinkmanvanderlinden et al., "ORAL ESTROGEN-TREATMENT INDUCES A DECREASE IN EXPRESSION OF SIALYL-LEWIS-X ON ALPHA(1)-ACID GLYCOPROTEIN IN FEMALES AND MALE-TO-FEMALE TRANSSEXUALS", Glycobiology, 6(4), 1996, pp. 407-412

Abstract

The effect of estrogen on the glycosylation of alpha(1)-acid glycoprotein was studied in women using oral contraceptives and in male-to-female transsexuals receiving oral or transdermal estrogen treatment, Oral estrogen treatment induced an increase in degree of branching and a decrease in fucosylation and sialyl Lewis x expression on alpha(1)-acid glycoprotein compared to individuals receiving no estrogens or transdermal estrogen treatment, The effect on the glycosylation of alpha(1)-acid glycoprotein was less in the male-to-female transsexuals receiving oral estrogens in combination with cyproterone acetate, a blocker of the androgen receptor with progestagen-like effects, This was of comparable magnitude as in women using oral contraceptives containing both estrogen and progestagen. We conclude that oral estrogens have an identical effect on the hepatic glycosylation of alpha(1)-acid glycoprotein in both males and females and that progestagen reduces this effect. These results show that oral estrogens induce an effect on the glycosylation of alpha(1)-acid glycoprotein opposite to that induced by inflammation, Oral estrogens can therefore modulate the glycosylation dependent inflammatory actions of alpha(1)-acid glycoprotein, while this is not the case with transdermal estrogens, In all likelihood, estrogen receptors on the hepatocyte must play a significant role in the observed effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 20:28:57