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Titolo:
DIFFERENTIAL-EFFECTS OF EMD-53998 ON CALCIUM-PRESSURE RELATIONSHIP INNORMAL AND ISCHEMIC GUINEA-PIG HEART
Autore:
ISHISU R; ABE Y; ONISHI K; SEKIOKA K; NAKANO T;
Indirizzi:
MITSUBISHI CHEM CORP,YOKOHAMA RES CTR,PHARMACEUT LAB 1,AOBA KU,1000 KAMOSHIDA YOKOHAMA KANAGAWA 227 JAPAN MIE UNIV,SCH MED,DEPT INTERNAL MED 1 TSU MIE 514 JAPAN
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 1, volume: 40, anno: 1996,
pagine: 311 - 319
SICI:
0363-6135(1996)40:1<311:DOEOCR>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
FERRET CARDIAC-MUSCLE; CARDIOTONIC AGENT; CONTRACTILE FAILURE; INTRACELLULAR CALCIUM; INORGANIC-PHOSPHATE; STUNNED MYOCARDIUM; CA2+ SENSITIZATION; INOTROPIC AGENTS; MAMMALIAN HEART; HYPOXIA;
Keywords:
INOTROPIC AGENTS; MYOCARDIAL ISCHEMIA; CONTRACTILE FUNCTION; CALCIUM TRANSIENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
R. Ishisu et al., "DIFFERENTIAL-EFFECTS OF EMD-53998 ON CALCIUM-PRESSURE RELATIONSHIP INNORMAL AND ISCHEMIC GUINEA-PIG HEART", American journal of physiology. Heart and circulatory physiology, 40(1), 1996, pp. 311-319

Abstract

We investigated the effects of EMD-53998 and digoxin on Ca2+ transients and left ventricular (LV) function in indo 1-loaded Langendorff guinea pig hearts. EMD-53998 (10(-9) to 10(-5) M) and digoxin (10(-10) to10(-6)M) increased +dP/dt and Ca2+ transients in normal hearts. The relative increase in Ca2+ transients by EMD-53998 was similar to digoxin. At 10(-5) M, EMD-53998 increased LV end-diastolic pressure. Low-flow ischemia decreased +dP/dt by 50%, while indo 1 ratio increased by 10-25%. EMD-53998 (10(-9) to 10(-6) M) effectively restored the depressed +dP/dt with little effect on indo 1 ratio, but at 10(-5) M, it markedly elevated LV end-diastolic pressure and the beneficial effect on contractile dysfunction disappeared. Digoxin (10(-10) to 10(-7) M) failed to improve LV function, but at 10(-6) M, it restored contractile dysfunction with a large increase in indo 1 ratio. The relation between indo 1 ratio and +dP/dt clearly showed that EMD-53998 restored contractile dysfunction by Ca2+ sensitization. These findings suggest that Ca2 sensitization by EMD-53998 is an advantageous approach for ischemic contractile failure but impairs diastolic function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:21:26