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Titolo:
BLOCKADE OF BRAIN OUABAIN PREVENTS SYMPATHOEXCITATORY AND PRESSOR-RESPONSES TO HIGH SODIUM IN SHR
Autore:
HUANG BS; LEENEN FHH;
Indirizzi:
UNIV OTTAWA,INST HEART,DIV CARDIOL,HYPERTENS UNIT,1053 CARLING AVE OTTAWA ON K1Y 4E9 CANADA UNIV OTTAWA,INST HEART,DIV CARDIOL,HYPERTENS UNIT OTTAWA ON K1Y 4E9 CANADA
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 1, volume: 40, anno: 1996,
pagine: 103 - 108
SICI:
0363-6135(1996)40:1<103:BOBOPS>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; SALT-INDUCED HYPERTENSION; SYMPATHETIC ACTIVITY; HUMAN-PLASMA; PERIPHERAL OUABAIN; DIETARY-SODIUM; NERVE ACTIVITY; RENAL NERVE; DAHL RATS; STRESS;
Keywords:
SODIUM INTAKE; ANTIBODY FAB FRAGMENTS; AIR STRESS; GUANABENZ; SPONTANEOUSLY HYPERTENSIVE RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
B.S. Huang e F.H.H. Leenen, "BLOCKADE OF BRAIN OUABAIN PREVENTS SYMPATHOEXCITATORY AND PRESSOR-RESPONSES TO HIGH SODIUM IN SHR", American journal of physiology. Heart and circulatory physiology, 40(1), 1996, pp. 103-108

Abstract

The effects of blockade of brain ''ouabain'' by central infusion of antibody Fab fragments, which bind ouabain and brain ''ouabain'' with high affinity, on sodium-sensitive hypertension were studied in spontaneously hypertensive rats (SHR) from 5 to 9 wk of age on high- or regular sodium diet. The Fab fragments or, in controls, gamma-globulins were infused intracerebroventricularly via osmotic minipump. Blood pressure (BP), heart rate (HR), and renal sympathetic nerve activity (RSNA) and their responses to air stress and to the alpha(2)-adrenoceptor agonist guanabenz intracerebroventricularly were recorded in conscious rats at 9 wk. In control SHR but not Wistar-Kyoto rats (WKY), high sodium further increased resting mean arterial pressure (171 +/- 3 vs. 141 /- 4 mmHg in control SHR on regular sodium) and potentiated excitatory and inhibitory responses of BP, HR, and RSNA to air stress and intracerebroventricular guanabenz, respectively. These effects of high sodium were all prevented by intracerebroventricular Fab fragments. In SHRon regular sodium or WKY on either diet, the Fab fragments had no effects on resting BP or responses to air stress and guanabenz. We conclude that similar to Dahl salt-sensitive rats, in SHR, a sodium-induced increase in brain ''ouabain'' is responsible for the decreased sympathoinhibition and increased sympathoexcitation and thus the exacerbationof hypertension. Brain ''ouabain'' appears not to be involved in the development of hypertension in SHR regular sodium intake.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 07:49:04