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Titolo:
THE COMBINATION OF PACLITAXEL WITH CISPLATIN EXHIBITS ANTAGONISM IN-VITRO AGAINST HUMAN-MELANOMA
Autore:
MOHITH A; PHOTIOU A; RETSAS S;
Indirizzi:
CHARING CROSS HOSP,DEPT MED ONCOL,CATHERINE GRIFFITHS CANC RES LAB,MELANOMA UNIT LONDON W6 8RF ENGLAND
Titolo Testata:
Anti-cancer drugs
fascicolo: 4, volume: 7, anno: 1996,
pagine: 493 - 498
SICI:
0959-4973(1996)7:4<493:TCOPWC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
TAXOL;
Keywords:
ANTAGONISM; CISPLATIN; CYTOTOXICITY; ISOBOLOGRAM; MELANOMA; PACLITAXEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
A. Mohith et al., "THE COMBINATION OF PACLITAXEL WITH CISPLATIN EXHIBITS ANTAGONISM IN-VITRO AGAINST HUMAN-MELANOMA", Anti-cancer drugs, 7(4), 1996, pp. 493-498

Abstract

The in vitro cytotoxicity of paclitaxel and cisplatin, alone and in combination, was evaluated against the established human melanoma cell line, G361, with either 1 or 24 h asynchronous paclitaxel exposure using the sulforhodamine B assay. As single agent, the mean cisplatin concentration which inhibited G361 cell growth by 50% (IC50) was 10 000 nM for 1 h exposure. IC50 values obtained with 1 24 h paclitaxel exposure were, and respectively, 63 and 3.8 nM, concentrations clinically achievable. The combination of paclitaxel with cisplatin was found to beantagonistic by the classical isobologram method, independent of drugsequence and of paclitaxel exposure time. The antagonism was significantly more pronounced for the sequence of paclitaxel followed by cisplatin compared with the reverse sequence for both 1 and 24 h paclitaxelexposure time (p < 0.05). Future clinical protocols employing paclitaxel and cisplatin, both active single agents for the treatment of metastatic malignant melanoma, should take into consideration that the combination of the two drugs may result in significant antagonism, irrespective of drug sequence, if administered within a short interval of each other.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 22:19:12