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Titolo:
CISPLATIN-INDUCED CHANGES IN BIOLOGICAL-ACTIVITY OF BLOOD-PLATELETS -THIOL-RELATED MECHANISMS
Autore:
OLAS B; WACHOWICZ B;
Indirizzi:
UNIV BANACHA,DEPT GEN BIOCHEM PL-90237 LODZ POLAND UNIV BANACHA,DEPT GEN BIOCHEM PL-90237 LODZ POLAND
Titolo Testata:
Anti-cancer drugs
fascicolo: 4, volume: 7, anno: 1996,
pagine: 476 - 482
SICI:
0959-4973(1996)7:4<476:CCIBOB>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTATHIONE; RESISTANCE; PLATINUM; CELLS; RATS; CYTOTOXICITY; NEPHROTOXICITY; HYPERTHERMIA; TOXICITY; PROTECTS;
Keywords:
BLOOD PLATELET; CISPLATIN; GLUTATHIONE; TRANSPLATIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
B. Olas e B. Wachowicz, "CISPLATIN-INDUCED CHANGES IN BIOLOGICAL-ACTIVITY OF BLOOD-PLATELETS -THIOL-RELATED MECHANISMS", Anti-cancer drugs, 7(4), 1996, pp. 476-482

Abstract

The effects of cisplatin (cis-diamminedichloroplatinum(II), CDDP) andtransplatin (trans-diamminedichloroplatinum(II), TDDP), and their complexes with glutathione (GS-Pt) in vitro on oxygen free radical generation (O-2(-.)), lipid peroxidation and ADP-induced aggregation in pig blood platelets were studied, Incubation of pig blood platelets with cisplatin or transplatin caused a loss of both protein -SH and the thiol groups of GSH. In pig blood platelets exposed to cisplatin or transplatin (20 mu M) the GS-Pt complex was formed as a major metabolite, The formation of GS-Pt complexes in platelet cytosol was time dependent and the intracellular content of this complex reached a maximal level after 24 h, GS-Pt complexes were found to induce platelet lipid peroxidation, measured as thiobarbituric acid reactive substance level, and 0(2)(-.) generation, and it was more active than cisplatin or transplatin alone. Cisplatin and its GS-Pt complex had an inhibitory effect onADP-induced platelet aggregation. These results showed that GS-Pt complexes affect platelet metabolism and function. It seems that glutathione-associated metabolism of platinum compounds plays an important role in the cytotoxicity and biological activity of these drugs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 12:07:09