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Titolo:
REDUCTION OF SEROTONERGIC FUNCTION IN RAT-BRAIN BY TRYPTOPHAN DEPLETION - EFFECTS IN CONTROL AND FLUVOXAMINE-TREATED RATS
Autore:
BEL N; ARTIGAS F;
Indirizzi:
CSIC,INST INVEST BIOMED,DEPT NEUROCHEM,JORDI GIRONA 18-26 E-08034 BARCELONA SPAIN CSIC,INST INVEST BIOMED,DEPT NEUROCHEM E-08034 BARCELONA SPAIN
Titolo Testata:
Journal of neurochemistry
fascicolo: 2, volume: 67, anno: 1996,
pagine: 669 - 676
SICI:
0022-3042(1996)67:2<669:ROSFIR>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID MIXTURES; FREELY MOVING RATS; INCREASES EXTRACELLULAR SEROTONIN; SPONTANEOUS FIRING RATE; MIDBRAIN RAPHE NUCLEI; DEPRESSED-PATIENTS; 5-HYDROXYINDOLEACETIC ACID; PLASMA TRYPTOPHAN; FRONTAL-CORTEX; 5-HYDROXYTRYPTAMINE RELEASE;
Keywords:
ANTIDEPRESSANTS; TRYPTOPHAN DEPLETION; 5-HYDROXYTRYPTAMINE SYNTHESIS; 5-HYDROXYTRYPTAMINE RELEASE; INTRACEREBRAL MICRODIALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
N. Bel e F. Artigas, "REDUCTION OF SEROTONERGIC FUNCTION IN RAT-BRAIN BY TRYPTOPHAN DEPLETION - EFFECTS IN CONTROL AND FLUVOXAMINE-TREATED RATS", Journal of neurochemistry, 67(2), 1996, pp. 669-676

Abstract

The administration of tryptophan (Trp)-free amino acid mixtures to depressed patients responding to serotonin [5-hydroxytryptamine (5-HT)] uptake inhibitors (SSRIs) worsens their clinical state. This procedurereduces Trp availability to brain and thus impairs 5-HT synthesis, Wehave examined the influence of Trp depletion on extracellular 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) concentrations in the rat brain using in vivo microdialysis. The treatment with the SSRI fluvoxamine significantly increased 5-HT content in dialysates from frontal cortex,as compared with control rats (10.2 +/- 2.7 vs. 3.1 +/- 0.4 fmol per fraction), whereas 5-HIAA was unaffected. Food deprivation for 20 h reduced dialysate 5-HT content to almost control values in fluvoxamine-treated rats (10.2 +/- 2.7 vs, 4.3 +/- 0.6 fmol per fraction) but did not alter dialysate 5-HIAA content (7.8 +/- 0.4 vs. 7.2 +/- 0.5 pmol per fraction), The administration of Trp-free amino acid mixtures to fluvoxamine-treated rats significantly attenuated the release of 5-HT in frontal cortex (similar to 50%) and, to a lesser extent, in the midbrain raphe nuclei. This effect was more marked in rats not deprived fromfood before the experiments (67% reduction of dialysate 5-HT content in frontal cortex) and was absent in control rats (treated with saline). In contrast, dialysate 5-HIAA was markedly affected by Trp depletion in all groups, including controls (65-75% reductions). These data show that the administration of an amino acid mixture with the same composition and dose (in milligrams per kilogram of body weight) as those inducing a severe mood impairment in depressed patients reduces 5-HT and 5-HIAA concentrations in brain dialysates. The reduction of 5-HT release, however, occurs only in animals previously treated with the antidepressant fluvoxamine for 2 weeks, which would be consistent with a marked reduction of 5-HT-mediated transmission in treated depressed patients but not in healthy controls.

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Documento generato il 09/08/20 alle ore 23:23:41