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Titolo:
SEIZURE ACTIVITY RESULTS IN A RAPID INDUCTION OF NUCLEAR FACTOR-KAPPA-B IN ADULT BUT NOT JUVENILE RAT LIMBIC STRUCTURES
Autore:
RONG YQ; BAUDRY M;
Indirizzi:
UNIV SO CALIF,NEUROSCI PROGRAM,HNB 311 LOS ANGELES CA 90089
Titolo Testata:
Journal of neurochemistry
fascicolo: 2, volume: 67, anno: 1996,
pagine: 662 - 668
SICI:
0022-3042(1996)67:2<662:SARIAR>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN DAMAGE SYNDROME; KAINIC ACID; TRANSCRIPTION FACTOR; STATUS EPILEPTICUS; NEURONAL INJURY; ACTIVATION; EXPRESSION; HIPPOCAMPUS; INHIBITOR; DNA;
Keywords:
TRANSCRIPTION FACTOR; NUCLEAR FACTOR-KAPPA-B; KAINATE; SEIZURE ACTIVITY; LIMBIC STRUCTURES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
Y.Q. Rong e M. Baudry, "SEIZURE ACTIVITY RESULTS IN A RAPID INDUCTION OF NUCLEAR FACTOR-KAPPA-B IN ADULT BUT NOT JUVENILE RAT LIMBIC STRUCTURES", Journal of neurochemistry, 67(2), 1996, pp. 662-668

Abstract

Previous studies have indicated that increased formation of oxygen free radicals is likely to participate in the cascade of events leading to neuronal damage following kainic acid (KA)-induced seizure activity. As reactive oxygen species are involved in signal transduction pathways leading to nuclear factor-kappa B (NF-kappa B) activation, we examined the effects of KA treatment on the activation of NF-kappa B in adult and juvenile rat brain. For comparison, changes in two other transcription factors, activator protein-1 (AP-1) and Spl, were also determined. In adult rat piriform cortex and hippocampus, significant induction of NF-kappa B was observed at 4 h after KA injection, and the maximal increase was reached at 8-16 h posttreatment. NF-kappa B binding activities returned to control levels by 5 days after injection. NF-kappa B binding activities were slightly decreased in adult rat cerebellum at 8 and 16 h after KA treatment. In the juvenile rat, no significant changes in NF-kappa B binding activity were observed in piriform cortex, hippocampus, and cerebellum after KA injection. Changes in AP-1 binding activity were qualitatively similar to those observed with NF-kappa B in adult but not juvenile rat brain, as AP-1 was significantly induced in juvenile piriform cortex and hippocampus following KA injection. On the other hand, little or no changes in Sp1 activity were detected in adult and juvenile rat brain. Our results provide further evidence that oxidative stress participates in neuronal damage resulting from KA-induced seizure activity.

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Documento generato il 18/01/21 alle ore 16:13:13