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Titolo:
HSV-TK GENE-THERAPY IN HEAD AND NECK SQUAMOUS-CELL CARCINOMA - ENHANCEMENT BY THE LOCAL AND DISTANT BYSTANDER EFFECT
Autore:
WILSON KM; STAMBROOK PJ; BI WL; PAVELIC ZP; PAVELIC L; GLUCKMAN JL;
Indirizzi:
UNIV CINCINNATI,DEPT OTOLARYNGOL,231 BETHESDA AVE CINCINNATI OH 45267 UNIV CINCINNATI,DEPT ANAT & CELL BIOL CINCINNATI OH 45267
Titolo Testata:
Archives of otolaryngology, head & neck surgery
fascicolo: 7, volume: 122, anno: 1996,
pagine: 746 - 749
SICI:
0886-4470(1996)122:7<746:HGIHAN>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-INFILTRATING LYMPHOCYTES; MURINE TUMOR; BRAIN-TUMORS; NECROSIS-FACTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
K.M. Wilson et al., "HSV-TK GENE-THERAPY IN HEAD AND NECK SQUAMOUS-CELL CARCINOMA - ENHANCEMENT BY THE LOCAL AND DISTANT BYSTANDER EFFECT", Archives of otolaryngology, head & neck surgery, 122(7), 1996, pp. 746-749

Abstract

Objective: To determine whether the bystander effect demonstrated in vitro for ganciclovir-mediated killing of a herpes simplex virus thymidine kinase (HSV-tk) gene-infected human squamous cell carcinoma is operative in vivo in a nude mouse model. Design: Prospective study in a murine model. Intervention: Human head and neck squamous cell carcinoma tumors were grown as xenografts on the flanks or 20 nude mice The tumors in the left flank were then infected with the HSV-tk gene. Then, after 48 hours, the animals were treated with intraperitoneal ganciclovir twice daily. Assessment of the turners on both flanks was performed over a 31-day period. Main Outcome Measures: Resolution of tumors infected with HSV-th gene in animals treated with ganciclovir; resolution of tumors uninfected with HSV-tk gene on the contralateral flank in animals created with ganciclovir. Results: Following HSV-th gene therapy in nude mice, complete resolution of HSV-tk-gene-infected human head and neck squamous cell carcinoma tumors was observed following ganciclovir treatment. Uninfected tumors were also noted to regress, but not completely resolve, in response to intraperitoneal ganciclovir (distant bystander effect). Conclusion: This study confirms that the local and distant bystander effects exist in this murine model, enhancing the possibility of its role for treatment of human squamous cell carcinoma of the head and neck.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:29:08