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Titolo:
HEMIN BINDING AS A FACTOR IN THE VIRULENCE OF PORPHYROMONAS-GINGIVALIS
Autore:
SMALLEY JW; BIRSS AJ; MCKEE AS; MARSH PD;
Indirizzi:
UNIV LIVERPOOL,DEPT CLIN DENT SCI,ORAL BIOL UNIT,EDWARDS BLDG LIVERPOOL L69 3BX MERSEYSIDE ENGLAND CTR APPL MICROBIOL & RES,DIV RES SALISBURY WILTS ENGLAND
Titolo Testata:
FEMS microbiology letters
fascicolo: 1, volume: 141, anno: 1996,
pagine: 65 - 70
SICI:
0378-1097(1996)141:1<65:HBAAFI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
BACTEROIDES-GINGIVALIS; HEMIN-BINDING; SURFACE PROTEIN; OUTER-MEMBRANE; EXTRACELLULAR VESICLES; PLEIOTROPIC MUTANTS; AVIRULENT VARIANT; W50; PORPHYROMONAS-(BACTEROIDES)-GINGIVALIS; BACTEROIDES-GINGIVALIS-W50;
Keywords:
PORPHYROMONAS GINGIVALIS; HEMIN; BINDING; VIRULENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
J.W. Smalley et al., "HEMIN BINDING AS A FACTOR IN THE VIRULENCE OF PORPHYROMONAS-GINGIVALIS", FEMS microbiology letters, 141(1), 1996, pp. 65-70

Abstract

Haemin (iron protoporphyrin IX) is an essential growth factor for theperiodontal pathogen, Porphyromonas gingivalis. Iron protoporphyrin M. (IPP IX) binding to the avirulent P. gingivalis beige variant (W50/BE1) and the black-pigmenting parent wild-type strain W50 was quantified. W50/BE1 grown in a chemostat under haemin excess-bound IPP IX under both oxidising and reducing conditions but with both lower capacity and avidity than either the haemin-limited- and haemin-excess-grown parent strain W50. Rosenthal plots for W50/BE1 indicated cooperative binding. W50/BE1 cells expressed a 32 kDa outer membrane haemin-binding protein when grown under conditions of haemin excess, and this strain might serve as a useful source from which to isolate this protein. The reduced IPP IX binding ability of W50/BE1 may be the rate-limiting factor for haem uptake and explain the reduced virulence and slower rate ofpigmentation of this strain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:22:04