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Titolo:
ELASTASE-INDUCED HYDROLYSIS OF SYNTHETIC SOLID SUBSTRATES - POLY(ESTER-UREA-URETHANE) AND POLY(ETHER-UREA-URETHANE)
Autore:
LABOW RS; ERFLE DJ; SANTERRE JP;
Indirizzi:
UNIV OTTAWA,INST HEART,CARDIOVASC DEVICES DIV OTTAWA ON K1Y 4E9 CANADA UNIV OTTAWA,DEPT BIOCHEM OTTAWA ON CANADA UNIV TORONTO,FAC DENT,DEPT BIOMAT TORONTO ON CANADA
Titolo Testata:
Biomaterials
fascicolo: 24, volume: 17, anno: 1996,
pagine: 2381 - 2388
SICI:
0142-9612(1996)17:24<2381:EHOSSS>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PORCINE PANCREATIC ELASTASE; HUMAN MONOCYTE-MACROPHAGES; HUMAN NEUTROPHIL ELASTASE; CATHEPSIN-G; POLYURETHANES; DEGRADATION; RELEASE; INHIBITORS; BIODEGRADATION; CHOLESTEROL;
Keywords:
POLY(URETHANE)S; BIODEGRADATION; NEUTROPHIL; INFLAMMATORY RESPONSE; HUMAN ELASTASE; PORCINE ELASTASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
R.S. Labow et al., "ELASTASE-INDUCED HYDROLYSIS OF SYNTHETIC SOLID SUBSTRATES - POLY(ESTER-UREA-URETHANE) AND POLY(ETHER-UREA-URETHANE)", Biomaterials, 17(24), 1996, pp. 2381-2388

Abstract

Human neutrophil elastase (HNE) and porcine pancreatic elastase (PPE)were incubated with two radiolabelled model poly(urethane)s, a poly(ester-urea-urethane) containing [C-14]toluene diisocyanate ([C-14]TDI),poly(caprolactone) (PCL) and ethylenediamine (ED), and a poly(ether-urea-urethane) containing [C-14]TDI, poly(tetramethylene oxide) (PTMO) and ED. Ten-fold more radioactive carbon was released when PPE was incubated with [C-14]TDI/PCL/ED than when HNE was used. The PPE-induced radioactive carbon release was significantly reduced by a specific elastase inhibitor. Ten-fold less radioactive carbon was released when [C-14]TDI/PTMO/ED was incubated with PPE as compared to [C-14]TDI/PCL/ED. Since neutrophils, which contain elastolytic activity, are present during the inflammatory response, the stability of biomaterials used in implanted devices may be affected. (C) 1996 Elsevier Science Limited

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/02/20 alle ore 08:20:51