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Titolo:
SURFACTANT-ASSOCIATED PROTEIN-A INHIBITS HUMAN LYMPHOCYTE-PROLIFERATION AND IL-2 PRODUCTION
Autore:
BORRON P; VELDHUIZEN RAW; LEWIS JE; POSSMAYER F; CAVENEY A; INCHLEY K; MCFADDEN RG; FRAHER LJ;
Indirizzi:
UNIV WESTERN ONTARIO,ST JOSEPHS HLTH CTR,LAWSON RES INST,DEPT MED,268GROSVENOR ST LONDON ON N6A 4V2 CANADA UNIV WESTERN ONTARIO,ST JOSEPHS HLTH CTR,LAWSON RES INST,DEPT OBSTET & GYNAECOL LONDON ON N6A 4V2 CANADA UNIV WESTERN ONTARIO,ST JOSEPHS HLTH CTR,LAWSON RES INST,DEPT BIOCHEMLONDON ON N6A 4V2 CANADA UNIV WESTERN ONTARIO,ST JOSEPHS HLTH CTR,LAWSON RES INST,DEPT PHYSIOLLONDON ON N6A 4V2 CANADA
Titolo Testata:
American journal of respiratory cell and molecular biology
fascicolo: 1, volume: 15, anno: 1996,
pagine: 115 - 121
SICI:
1044-1549(1996)15:1<115:SPIHL>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL ACTIVATION; PULMONARY SURFACTANT; ALVEOLAR MACROPHAGES; ACTIVE MATERIAL; BRONCHOALVEOLAR LYMPHOCYTES; IMMUNOREGULATORY PROPERTIES; BINDING PROTEINS; LUNG; ANTIGEN; APOPROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
P. Borron et al., "SURFACTANT-ASSOCIATED PROTEIN-A INHIBITS HUMAN LYMPHOCYTE-PROLIFERATION AND IL-2 PRODUCTION", American journal of respiratory cell and molecular biology, 15(1), 1996, pp. 115-121

Abstract

The hyporesponsive state of lung-derived mononuclear leukocytes has been, in part, attributed to the effects of the lipid rather than the protein components of pulmonary surfactant. In the present study, however ever, the results suggest that purified preparations of pulmonary surfactant-associated protein A (SP-A) suppress both phytohemagglutinin(PHA, 1 mu g/ml)- and anti-CD-3 (1 to 10 ng/ml) activated proliferation of human peripheral blood and tonsillar mononuclear cells in a dose-dependent manner at concentrations as low as 50 pM (6.25 mu g/ml) when added at the initiation of cultures. Addition of SP-A to PHA-stimulated peripheral blood mononuclear cells (PBMC) as late as 24 to 36 h after PHA was also capable of suppressing [H-3]thymidine incorporation measured at 72 h. In contrast. concanavalin A (Con A; 2 mu g/ml)-stimulated PBMC proliferation was slightly augmented by the addition of SP-A. Analysis of the supernatants of PHA-stimulated cultures treated withSP-A revealed that accompanying the inhibition of proliferation was acorresponding decline in measurable interleukin-2 (IL-2) concentrations, from 154 pg/ml for the PHA-treated cells to 57.8, 28.4, 5.2, and less than 2 pg/ml of IL-2 when SP-A was added at 6.25, 12.5, 25, and 50mu g/ml, respectively. We suggest that the action of SP-A on PHA-stimulated human PBMC may involve the blocking of a costimulatory signal crucial for in vitro T-cell activation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 08:22:51