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Titolo:
4 CASES OF HEMOLYTIC-UREMIC-SYNDROME - SOURCE-CONTAMINATED SWIMMING-WATER
Autore:
CRANSBERG K; VANDENKERKHOF JHCT; BANFFER JRJ; STIJNEN C; WERNARS K; VANDEKAR NCAJ; NAUTA J; WOLFF ED;
Indirizzi:
SOPHIA CHILDRENS UNIV HOSP,DEPT PEDIAT NEPHROL,DR MOLEWATERPLEIN 60 NL-3015 GJ ROTTERDAM NETHERLANDS LOCAL HLTH AUTHOR DORDRECHT NETHERLANDS CENT BACTERIOL LAB ROTTERDAM NETHERLANDS NATL INST PUBL HLTH & ENVIRONM PROTECT NL-3720 BA BILTHOVEN NETHERLANDS UNIV NIJMEGEN HOSP,DEPT PED NEPHROL NL-6500 HB NIJMEGEN NETHERLANDS
Titolo Testata:
Clinical nephrology
fascicolo: 1, volume: 46, anno: 1996,
pagine: 45 - 49
SICI:
0301-0430(1996)46:1<45:4COH-S>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESCHERICHIA-COLI O157-H7; HEMORRHAGIC COLITIS; OUTBREAK;
Keywords:
HEMOLYTIC UREMIC SYNDROME; SWIMMING ASSOCIATED CASES; CONTAMINATED WATER; ESCHERICHIA-COLI 0157-H7;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
K. Cransberg et al., "4 CASES OF HEMOLYTIC-UREMIC-SYNDROME - SOURCE-CONTAMINATED SWIMMING-WATER", Clinical nephrology, 46(1), 1996, pp. 45-49

Abstract

In June '93, 4 children, aged 1.5-3.5 years, all living in one town, were admitted to our hospital with the diagnosis hemolytic uremic syndrome (HUS) within one week. In cooperation with the local health authorities a common source was searched for. Questionnaires indicated thatthe single condition shared by all patients was swimming water. The patients were not acquainted, visited different daycares, and had no food resources in common. All 4 patients bathed in the same, shallow, recreational lake within a period of 5 days. During this time the air temperature was high according to Dutch standards (around 27 degrees C),and many people visited the lake, estimated several hundreds a day. The water level was lower than normal. Diarrhea followed 3-11 days after swimming and the first clinical symptoms of HUS developed 6-7 days after the onset of diarrhea. The lake was closed for swimming when the fourth HUS patient was diagnosed and the possibility of transmission by way of the lake was mentioned. E. coli O157:H7 was demonstrated in the fecal samples of 2 index patients. The samples were taken 9-20 daysafter the start of diarrhea. Antibodies to O157 and verotoxin 2 were strongly positive in all patients. A local outbreak of diarrheal illness was not registered. Of 16 family members who also swam in the same lake, 7 developed symptoms of enteritis, 3 had positive cultures of their fecal samples and 5 had positive serology. Pulsed-field gel electrophoresis of the E. coli isolates of the patients and family members showed an identical pattern. No O157:H7-DNA could be detected in filterconcentrated lake water samples using polymerase chain reaction (PCR)enhancement. These samples were, however, taken 16 days after the latest possible date of contamination of our patients, 15 days after decrease of the air temperature to 15-17 degrees C, and 14 days after the inlet from water from the environment. It could thus very well be thatthe microorganism was no longer present. This third report of swimming water associated HUS should direct environmental surveys in similar cases of local HUS outbreaks.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 16:49:16