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Titolo:
CLINICAL VS PHOTOGRAPHIC ASSESSMENT OF TREATMENT OF CYTOMEGALOVIRUS RETINITIS - FOSCARNET-GANCICLOVIR CYTOMEGALOVIRUS RETINITIS TRIAL REPORT-8
Autore:
LEWIS RA; CLOGSTON P; FAINSTEIN V; GROSS R; SAMO TC; TUTTLE C; JABS DA; APUZZO L; BARTLETT J; COLESON L; DUNN JP; ELDRED L; FEINBERG J; FLYNN T; KING R; LESLIE J; BARRON B; GREENSPAN D; LECOUNT C; PEYMAN G; FRANKLIN R; HEINEMANN MH; POLSKY B; SQUIRES K; WISECAMPBELL S; FRIEDMAN AH; CHEUNG TW; JUSTIN N; TEICH S; SACKS H; SEVERIN C; ADDESSI A; DIETERICH D; FROST K; WEINBERG D; JAMPOL L; MURPHY R; NAUGHTON K; HENDERLY D; HOLLAND GN; CHAFEY S; FALL H; HARDY WD; KIMBRELL C; MACARTHURCHANG L; FREEMAN WR; MEINERT L; PETERSON TJ; QUICENO JI; RICKMAN L; SIMANELLO MA; SPECTOR S; ODONNELL J; HOFFMAN J; IRVINE A; JACOBSON M; LARSON J; SEIFF S; WANNER M; DAVIS J; CHUANG E; ESPINAL M; MENDEZ P; VANDENBROUCKE R; CHEESMAN SH; GITTINGER J; HAUBRICH R; KACHADOORIAN H; TOLSON K; KLINE JM; KLEMM AC; STEVENS M; WEBB R; BROWNBELLAMY J; MARKOWTIZ JA; MEINERT CL; BROOKMEYER R; COLLINS KB; COLLISON BJ; DODGE J; DONITHAN M; FINK N; GILPIN AMK; GERCZAK C; HOLBROOK JT; ISAACSON MR; LEVINE CR; MARTIN B; MIN YI; MEINERT JL; OWENS RM; NOWAKOWSKI DJ; SAAH A; SINGER S; SMITH M; STERNBERG AL; TONASCIA J; VANNATTA ML; DAVIS MD; AGRESSEGAL M; ARMSTRONG J; BRICKBAUER J; BROTHERS R; FREITAG G; HUBBARD L; HURLBURT D; JENSEN K; KASTORFF L; KING B; MAGLI Y; MESSING S; MINER K; NEIDER M; ONOFREY J; STOPPENBACH V; THOMAS S; VANDERHOOFYOUNG M; STEWART G; HUGHES R; WELCH L; KURINIJ N; MOWERY R; ELLENBERG S; KORVICK J; CLARK T; CLOGSTON PS; FREEMAN W; HOLBROOK JT; KOLVICK J; MARKOWITZ JA; SATTLER F; CONWAY B; GRIZZLE J; NUSSENBLATT R; PHAIR J; SMITH H; WHITLEY R; CHENG B; LAMBERT AG; LINK D;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,WILMER OPHTHALMOL INST,SOCA CHAIRMANS OFF,550 N BROADWAY,SUITE 700 BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,WILMER OPHTHALMOL INST,SOCA CHAIRMANS OFF BALTIMORE MD 21205
Titolo Testata:
Archives of ophthalmology
fascicolo: 7, volume: 114, anno: 1996,
pagine: 848 - 855
SICI:
0003-9950(1996)114:7<848:CVPAOT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
4
Recensione:
Indirizzi per estratti:
Citazione:
R.A. Lewis et al., "CLINICAL VS PHOTOGRAPHIC ASSESSMENT OF TREATMENT OF CYTOMEGALOVIRUS RETINITIS - FOSCARNET-GANCICLOVIR CYTOMEGALOVIRUS RETINITIS TRIAL REPORT-8", Archives of ophthalmology, 114(7), 1996, pp. 848-855

Abstract

Objective: To illustrate 2 common problems encountered in evaluating the response of cytomegalovirus retinitis to antiviral treatment and to consider their clinical importance. Methods: Four illustrative caseswere selected from 76 cases reviewed during a study that compared clinical evaluation and centralized grading of fundus photographs in the assessment of cytomegalovirus retinitis. Results: These cases illustrate 2 problems noted during the review: (1) that progression of retinitis may be difficult to recognize clinically in the absence of an obvious increase in retinitis border activity and (2) that movement of retinitis borders by 750 mu m or more (the principal criterion used to define retinitis progression) during the initial 4 weeks of treatment does not necessarily represent an unfavorable response to treatment. Conclusions: Ophthalmologists who participate in the management of cytomegalovirus retinitis should be aware of the subtlety of retinitis activity that sometimes accompanies progression in patients undergoing treatment with currently approved agents. Side-by-side comparison of good-quality photographs from the current visit (as soon as they are available) with photographs from previous visits, using adequate illuminationand magnification, may be helpful in detecting progression promptly. When applying the results of clinical trials to clinical practice, clinicians should not equate retinitis border movement of 750 mu m or more during the first 4 weeks of treatment with treatment failure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 03:19:58