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Titolo:
EFFECT OF PHOSPHATIDYLSERINE ON THE BINDING-PROPERTIES OF GLUTAMATE RECEPTORS IN BRAIN SECTIONS FROM ADULT AND NEONATAL RATS
Autore:
GAGNE J; GIGUERE C; TOCCO G; OHAYON M; THOMPSON RF; BAUDRY M; MASSICOTTE G;
Indirizzi:
UNIV QUEBEC,DEPT CHIM BIOL,CP 500 TROIS RIVIERES PQ G9A 5H7 CANADA UNIV QUEBEC,DEPT CHIM BIOL TROIS RIVIERES PQ G9A 5H7 CANADA UNIV SO CALIF,NEUROSCI PROGRAM LOS ANGELES CA 90089 CTR RECH PHILIPPE PINEL MONTREAL PQ H1C 1H1 CANADA
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 740, anno: 1996,
pagine: 337 - 345
SICI:
0006-8993(1996)740:1-2<337:EOPOTB>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; MEMBRANE PHOSPHOLIPID ASYMMETRY; H-3 AMPA BINDING; SYNAPTIC TRANSMISSION; QUISQUALATE RECEPTORS; BLOOD-PLATELETS; CRITICAL PERIOD; NMDA RECEPTORS; RED-CELLS; EXPRESSION;
Keywords:
PHOSPHOLIPID; GLUTAMATE RECEPTOR; HIPPOCAMPUS; DEVELOPMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
J. Gagne et al., "EFFECT OF PHOSPHATIDYLSERINE ON THE BINDING-PROPERTIES OF GLUTAMATE RECEPTORS IN BRAIN SECTIONS FROM ADULT AND NEONATAL RATS", Brain research, 740(1-2), 1996, pp. 337-345

Abstract

The effects of phosphatidylserine (PS) on the binding properties of the AMPA (alpha-amino-3-hydroxy-5-methylisoxazolepropionic acid) and NMDA (N-methyl-D-aspartate) subtypes of glutamate receptors were analyzed by quantitative autoradiography of [H-3]AMPA, [H-3]6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and [H-3]glutamate binding on rat brain tissue sections. Preincubation of brain sections with PS produced an increase in [H-3]AMPA binding without modifying the binding properties of [H-3]CNQX, an antagonist of AMPA receptors. This effect of PS appearedto be specific for the AMPA subtype of glutamate receptors as the same treatment did not modify [H-3]glutamate binding to the NMDA receptors. Furthermore, the PS-induced increase in [H-3]AMPA binding was different in various brain structures, being larger in the molecular layer of the cerebellum and almost absent in the striatum. Preincubation with calcium also augmented [H-3]AMPA binding, and the lack of additivityof the effects of calcium and PS on [H-3]AMPA binding strongly suggests that both treatments share a common mechanism(s) for producing increased agonist binding. Finally, the effect of PS on AMPA receptor properties was markedly reduced in rat brain sections prepared from neonatal rats at a developmental stage that is normally characterized by theabsence of LTP expression in certain brain regions. The present data are consistent with the hypothesis that alteration in the lipid composition of synaptic membranes may be an important mechanism for regulating AMPA receptor properties, which could be involved in producing long-lasting changes in synaptic operation.

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Documento generato il 21/01/21 alle ore 02:17:04