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Titolo:
EFFICACY OF TROXERUTIN IN PATIENTS WITH CHRONIC VENOUS INSUFFICIENCY - A DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY
Autore:
INCANDELA L; DESANCTIS MT; CESARONE MR; LAURORA G; BELCARO G; TACCOEN A; GERENTES I;
Indirizzi:
PIERANGELI CLIN I-65100 PESCARA ITALY
Titolo Testata:
Advances in therapy
fascicolo: 3, volume: 13, anno: 1996,
pagine: 161 - 166
SICI:
0741-238X(1996)13:3<161:EOTIPW>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
AGGREGATION;
Keywords:
CHRONIC VENOUS INSUFFICIENCY; MICROCIRCULATION; RED BLOOD CELL AGGREGATION; RHEOLOGY; TROXERUTIN; VARICOSE VEINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
L. Incandela et al., "EFFICACY OF TROXERUTIN IN PATIENTS WITH CHRONIC VENOUS INSUFFICIENCY - A DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY", Advances in therapy, 13(3), 1996, pp. 161-166

Abstract

Chronic venous insufficiency (CVI) is associated with microcirculatory changes that can be investigated with laser Doppler flowmetry, transcutaneous oximetry, and capillaroscopy. Disturbances in blood flow andred cell properties have also been described in patients with hypertensive venous microangiopathy. This double-blind, placebo-controlled, 8-week study investigated the effects of troxerutin on microcirculatorychanges in 30 patients with the skin changes of CVI who were enrolledafter undergoing color duplex and light-reflection rheography. A venous refilling time of less than 15 seconds indicated significant reflux. Perimalleolar resting flow of greater than 1.5 U and altered venoarteriolar response were assessed by laser Doppler flowmetry. At study end, a nonsignificant reduction in resting flow (11.9%) and improved venoarteriolar response (21.8%) were observed in the patients who received troxerutin but not in those given placebo. In addition, significant improvements were noted in transcutaneous Po-2 and red blood cell aggregation in the troxerutin-treated patients. Additional studies with more patients are needed to confirm our results.

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Documento generato il 24/09/20 alle ore 21:02:26