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Titolo:
FUNCTIONAL IMPROVEMENT IN CORONARY-ARTERY DISEASE AFTER 20 MONTHS OF LIPID-LOWERING THERAPY WITH POLICOSANOL
Autore:
BATISTA JF; STUSSER RJ; PADRON R; SOSA F; PEREZTOL O; PEREZ B;
Indirizzi:
CTR INVEST CLIN,CALLE 34 4501 ENTRE 47 & 45 HAVANA 13 CUBA UNIV HAVANA,CLIN RES CTR,DEPT CLIN EPIDEMIOL & BIOSTAT HAVANA CUBA
Titolo Testata:
Advances in therapy
fascicolo: 3, volume: 13, anno: 1996,
pagine: 137 - 148
SICI:
0741-238X(1996)13:3<137:FIICDA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-DISEASE; ATHEROSCLEROSIS; EXERCISE;
Keywords:
CORONARY ARTERY DISEASE; EJECTION FRACTION; LIPID-LOWERING DRUG; MAXIMUM OXYGEN UPTAKE; POLICOSANOL; (201)THALLIUM-LABELED MYOCARDIAL PERFUSION SCINTIGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
J.F. Batista et al., "FUNCTIONAL IMPROVEMENT IN CORONARY-ARTERY DISEASE AFTER 20 MONTHS OF LIPID-LOWERING THERAPY WITH POLICOSANOL", Advances in therapy, 13(3), 1996, pp. 137-148

Abstract

To examine the effects of long-term lipid-lowering therapy with policosanol on coronary artery disease (CAD), a 20-month exploratory phase II, randomized, blinded, placebo-controlled trial was conducted in 45 patients with ischemia, as documented by tomographic (201)-thallium-labeled myocardial perfusion scintigraphy ((TI)-T-201 MPS). Fifteen patients received policosanol 5 mg twice daily, 15 patients received policosanol 5 mg twice daily plus aspirin 125 mg, and 15 patients received placebo plus aspirin. Ischemic segments (IS) were assessed serially byMPS in regions not related to infarcted areas. Exercise electrocardiography, bidimensional echocardiographic examination, and serum lipid tests were also performed. Forty-one patients completed the follow-up study, 38 with primary hyperlipidemia, 37 with a prior myocardial infarction. Proportions of functional nonprogression of IS in the groups taking policosanol alone (.75) and policosanol plus aspirin (.73) were double those of the group receiving placebo plus aspirin (.36) (P = .04, chi(1df)(2) = 4.01; P = .04, chi(1df)(2) = 4.14) Sets of mean changes after treatment of IS, maximum oxygen uptake, and left ventricular ejection fraction improved simultaneously with policosanol therapy (P =.066, F-3.22df = 2.76; P = .006, F-3.25df = 5.19) but remained impaired without it. Lipid parameters were also evaluated. Results suggest that long-term lipid-lowering therapy with policosanol improves myocardial ischemia, exercise capacity, and left ventricular function in CAD patients. This response was enhanced when policosanol was given with aspirin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 05:42:01