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Titolo:
MOLECULAR-BIOLOGY OF PEDIATRIC GLIOMAS
Autore:
RAFFEL C;
Indirizzi:
MAYO CLIN & MAYO FDN,DEPT NEUROL SURG ROCHESTER MN 55905
Titolo Testata:
Journal of neuro-oncology
fascicolo: 2-3, volume: 28, anno: 1996,
pagine: 121 - 128
SICI:
0167-594X(1996)28:2-3<121:MOPG>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN BRAIN-TUMORS; NEUROFIBROMATOSIS TYPE-1 GENE; WILD-TYPE P53; PRIMITIVE NEUROECTODERMAL TUMORS; HUMAN GLIOBLASTOMA-MULTIFORME; HUMAN-MALIGNANT ASTROCYTOMA; POLYMERASE CHAIN-REACTION; NERVOUS-SYSTEM TUMORS; LOW-GRADE; SUPPRESSOR GENE;
Keywords:
PEDIATRIC GLIOMA; ASTROCYTOMA; EPENDYMOMA; ONCOGENESIS; GENETIC ALTERATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
92
Recensione:
Indirizzi per estratti:
Citazione:
C. Raffel, "MOLECULAR-BIOLOGY OF PEDIATRIC GLIOMAS", Journal of neuro-oncology, 28(2-3), 1996, pp. 121-128

Abstract

The genes involved in the genesis and progression of adult astrocytictumors have been an area of considerable investigation. The tumor suppressor gene, p53, has been implicated, as has the epidermal growth factor receptor gene. Additional currently unidentified genes lie on chromosomes 10 and 19. Interestingly, work on pediatric astrocytomas suggests that the genes involved are different. p53 is rarely mutated in pediatric tumors, the epidermal growth factor receptor gene is rarely amplified or mutated, and chromosome 10 deletions are rare. The only pediatric tumor that seems to mimic the findings in adult tumors is brainstem glioma, perhaps explaining the uniformly grim prognosis in this type of tumor. In the pilocytic astrocytoma of childhood, mutations inthe neurofibromatosis type I gene have been implicated in tumor development. In this review, the oncogenesis of pediatric gliomas is discussed and compared and contrasted to what is known about tumors.

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Documento generato il 02/10/20 alle ore 02:04:03