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Titolo:
CYP2D6 ALLELIC FREQUENCIES IN YOUNG-ONSET PARKINSONS-DISEASE
Autore:
SANDY MS; ARMSTRONG M; TANNER CM; DALY AK; DIMONTE DA; LANGSTON JW; IDLE JR;
Indirizzi:
CALIF ENVIRONM PROTECT AGCY,2151 BERKELEY WAY,ANNEX 11 BERKELEY CA 94704 PARKINSONS INST SUNNYVALE CA 00000 UNIV NEWCASTLE UPON TYNE,SCH MED,DEPT PHARMACOL SCI,PHARMACOGENET RESUNIT NEWCASTLE TYNE NE1 7RU TYNE & WEAR ENGLAND
Titolo Testata:
Neurology
fascicolo: 1, volume: 47, anno: 1996,
pagine: 225 - 230
SICI:
0028-3878(1996)47:1<225:CAFIYP>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEBRISOQUINE 4-HYDROXYLASE CYP2D6; HYDROXYLASE GENE POLYMORPHISM; POOR METABOLIZER PHENOTYPE; EXTENSIVE METABOLIZERS; LOCUS; IDENTIFICATION; MEPHENYTOIN; DNA; SUSCEPTIBILITY; AMPLIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
M.S. Sandy et al., "CYP2D6 ALLELIC FREQUENCIES IN YOUNG-ONSET PARKINSONS-DISEASE", Neurology, 47(1), 1996, pp. 225-230

Abstract

Parkinson's disease (PD) is thought to develop as a result of interactions between genetic susceptibility factors and environmental exposures. One candidate gene is CYP2D6, which codes for the debrisoquine 4-hydroxylase cytochrome P450. Impairment of debrisoquine 4-hydroxylase activity has been associated with an increased risk of PD in patients with younger age at disease onset. Genotyping studies in patients with an older age at onset have reported modest increases in risk associated with the CYP2D6 B and A alleles; however, the risk for young-onset PD has not been adequately evaluated. We designed a case-control study to investigate the role of nonfunctional CYP2D6 allelic risk factors for young-onset PD in a sizable patient population and compared the distributions of CYP2D6 genotypes between young-onset (less than or equalto 51 years) PD patients (n = 108) and controls (n = 236). In contrast with the results from genotyping studies conducted among patients with an older age at onset, there were no significant differences in CYP2D6 allelic frequencies between young-onset PD cases and controls. Thefrequency of the B allele was slightly lower in the young-onset PD cases than in the controls (0.14 versus 0.20) (chi(2) = 2.66, p = 0.10). The presence of one or more B alleles was not associated with an increased risk of young-onset PD (odds ratio 0.58; 95% CI 0.33 to 1.00), nor was the presence of one or more nonfunctional alleles (i.e., A, B, D, and D2) (odds ratio 0.68; 95% CI 0.41 to 1.13). This study suggeststhat the young-onset PD population may differ from the older-onset population with respect to risk factors.

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Documento generato il 08/07/20 alle ore 07:43:08