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Titolo:
EVALUATION OF A NEW, INTEGRAL, WHOLE-BLOOD FILTER (RS2000) SYSTEM FORPRESTORAGE LEUCODEPLETION OF SAG-M RED-CELLS
Autore:
RIDER JR; MOORE G; PAYRAT JM; CHAN D; MORSE C; STANDEN GR; PAMPHILON DH;
Indirizzi:
BRISTOL INST TRANSFUS SCI,NATL BLOOD SERV SW,SOUTHMEAD RD BRISTOL BS10 5ND AVON ENGLAND BAXTER R&D EUROPE NIVELLES BELGIUM BRISTOL ROYAL INFIRM & GEN HOSP BRISTOL AVON ENGLAND
Titolo Testata:
British Journal of Haematology
fascicolo: 1, volume: 94, anno: 1996,
pagine: 184 - 190
SICI:
0007-1048(1996)94:1<184:EOANIW>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSFUSION; PRODUCTS;
Keywords:
LEUCODEPLETION; WHOLE BLOOD; FILTRATION; RED CELL STORAGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
J.R. Rider et al., "EVALUATION OF A NEW, INTEGRAL, WHOLE-BLOOD FILTER (RS2000) SYSTEM FORPRESTORAGE LEUCODEPLETION OF SAG-M RED-CELLS", British Journal of Haematology, 94(1), 1996, pp. 184-190

Abstract

Residual donor leucocytes are responsible for many adverse transfusion reactions, Prestorage leucodepletion may ameliorate these effects and enhance product quality, We studied a bottom and top (BAT) system incorporating an integral filter for whole blood leucodepletion. Our evaluation assessed leucodepletion efficiency as well as in vitro SAG-M red cell quality and storage characteristics. Sixty-six units of blood were collected; test units into the Optipac(R)-pLuS system and controls into the standard triple pack configuration, Test units were held for 4-6 h at room temperature (rt) or 12-18 h at 4 degrees C, The mean leucocyte counts for the SAG-M red cells in the quality and storage trial were 0 . 6, x 10(6) (rt hold), 0 . 05 x 10(6) (4 degrees C hold) and 2500 x 10(6) (controls). We observed no significant differences between the groups for Na+, ATP, 2,3-DPG, glucose, lactate and pH during the 49 d storage. The control group, however. showed a greater increasein haemolysis and K+ with time. Autologous in vivo 24 h red cell recovery, after 42 d storage, was > 75%. Adjustment of processing parameters in subsequent studies gave leucodepleted SAG-M red cells with minimal cell loss (9-19%) plus acceptable haemoglobin content (46-76 g/U) and haematocrit (54-62%). This system achieved > 3 . 5 log leucodepletion with all but one unit containing < 1 x 10(6) leucocytes. The product quality is good and the system suitable for routine use in blood centres.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 06:37:58