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Titolo:
MALIGNANT-MELANOMA OF THE HEAD AND NECK - CLINICAL AND IMMUNOLOGICAL CONSIDERATIONS
Autore:
MERIMSKY O; FISHMAN P; FELDMAN I; SHAFIR R; RAPAPORT Y; SHEONFELD Y; CHAITCHIK S;
Indirizzi:
TEL AVIV UNIV,TEL AVIV SOURASKY MED CTR,DEPT ONCOL,6 WEIZMAN ST IL-64249 TEL AVIV ISRAEL TEL AVIV UNIV,TEL AVIV SOURASKY MED CTR,DEPT PLAST SURG IL-64249 TEL AVIV ISRAEL TEL AVIV UNIV,TEL AVIV SOURASKY MED CTR,DEPT OTOLARYNGOL IL-64249 TELAVIV ISRAEL TEL AVIV UNIV,SACKLER SCH MED IL-69978 TEL AVIV ISRAEL GOLDA MEIR MED CTR,RES INST PETAH TIQWA ISRAEL BAR ILAN UNIV RAMAT GAN ISRAEL CHAIM SHEBA MED CTR,DEPT INTERNAL MED B IL-52621 TEL HASHOMER ISRAEL
Titolo Testata:
American journal of clinical oncology
fascicolo: 4, volume: 19, anno: 1996,
pagine: 363 - 367
SICI:
0277-3732(1996)19:4<363:MOTHAN>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGNOSTIC FACTORS; SKIN MELANOMA; SURVIVAL; ANTIBODIES; RADIATION; VITILIGO; LOCATION;
Keywords:
MELANOMA; HEAD AND NECK; ANTIMELANOMA ANTIBODIES; ANTI-TYROSINASE ANTIBODIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
O. Merimsky et al., "MALIGNANT-MELANOMA OF THE HEAD AND NECK - CLINICAL AND IMMUNOLOGICAL CONSIDERATIONS", American journal of clinical oncology, 19(4), 1996, pp. 363-367

Abstract

Prolonged exposure to sun for long periods during most of the year has led to an increase in the frequency of malignant melanoma in Israel,especially for head and neck (H & N) melanoma. H & N melanoma is found in males more than in females and diagnosed when already locally advanced. The disease-free interval between treatment of the primary lesion and recurrence of the disease correlated with the patient's age andthe depth of invasion according to Breslow. A higher recurrence rate correlated with male gender, location in the scalp, and the stage of the disease. Metastatic disease involved the lungs, liver, and brain and responded poorly to systemic therapy. Improved survival was related to female gender, early stage of the disease, low Breslow thickness, and location of the primary lesion elsewhere than the scalp. Immunologically, we found that the titers of antimelanoma antibodies in patientswith metastatic disease originating in the area of the head and neck were higher than the titer in disease-free H & N melanoma patients (p = 0.05). Moreover, patients with metastatic H & N melanoma had a higher titer of antityrosinase antibodies compared with healthy subjects. These two types of antibodies might be used as markers for disease progression in H & N melanoma. The more aggressive character of H & N melanoma was not reflected by different titers of antimelanoma antibodies nor by antityrosinase antibodies in patients with H & N versus non-H &N melanoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 13:47:48