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Titolo:
HETEROGENEOUS EFFECTS OF G-CSF AND GM-CSF ON CELL-GROWTH AND ARA-C CYTOTOXICITY IN CHILDHOOD LEUKEMIAS WHICH EXPRESS MYELOID MARKERS
Autore:
HIGASHIGAWA M; KUWABARA H; CAO DC; HORI H; OHKUBO T; KAWASAKI H; IDO M; KOMADA Y; SAKURAI M;
Indirizzi:
MIE UNIV,SCH MED,DEPT PEDIAT,2-174 EDOBASHI TSU MIE 514 JAPAN
Titolo Testata:
Leukemia & lymphoma
fascicolo: 3-4, volume: 22, anno: 1996,
pagine: 279 - 285
SICI:
1042-8194(1996)22:3-4<279:HEOGAG>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; ACUTE LYMPHOBLASTIC-LEUKEMIA; CYTOSINE-ARABINOSIDE; ANTIGEN EXPRESSION; GRANULOCYTE; CHEMOTHERAPY; NEUTROPENIA; SENSITIVITY; CHILDREN; CULTURE;
Keywords:
G-CSF; GM-CSF; ARA-C; MTT ASSAY; [H-3] THYMIDINE; INCORPORATION ASSAY; MIXED LINEAGE LEUKEMIA; BIPHENOTYPIC LEUKEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
M. Higashigawa et al., "HETEROGENEOUS EFFECTS OF G-CSF AND GM-CSF ON CELL-GROWTH AND ARA-C CYTOTOXICITY IN CHILDHOOD LEUKEMIAS WHICH EXPRESS MYELOID MARKERS", Leukemia & lymphoma, 22(3-4), 1996, pp. 279-285

Abstract

It is uncertain if acute lymphoblastic leukemia (ALL) cells expressing myeloid makers can respond to granulocyte colony-stimulating factor (G-CSF) and granulocyte macrophage colony-stimulating factor (GM-CSF). We investigated the effects of G-CSF (0.01 mu g/ml) and GM-CSF (0.01 mu g/ml) on [H-3]thymidine (TdR) uptake, and the cytotoxicity of 1-beta-D-arabinofuranosylcytosine (ara-C) in leukemia cells from 17 pediatric patients. ALL cells without myeloid markers did not respond to G-CSF or GM-CSF, On the other hand, these cytokines enhanced the [H-3]TdR uptake and cell growth, not only of AML cells but also of ALL cells expressing myeloid antigens. However, G-CSF and GM-CSF did not always enhance the growth inhibitory effect of the cell cycle specific drug ara-C when the cells were co-cultured with the drug. There was no relationship between cell growth and the amount of [H-3]TdR incorporation or the intracellular ara-CTP level. These results indicate the heterogeneous effects of G-CSF and GM-CSF on cell growth and ara-C sensitivity in childhood leukemia cells.

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Documento generato il 04/04/20 alle ore 01:39:28