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Titolo:
RETROGRADE OXYGEN PERSUFFLATION IN COMBINATION WITH UW SOLUTION ENHANCES ADENINE-NUCLEOTIDE CONTENTS IN ISCHEMICALLY DAMAGED RAT-KIDNEY DURING COLD-STORAGE
Autore:
YIN M; BOOSTER MH; VANDERVUSSE GJ; MAESSEN JG; BUURMAN WA; KOOTSTRA G;
Indirizzi:
UNIV LIMBURG HOSP,DEPT SURG,POB 5800 NL-6202 AZ MAASTRICHT NETHERLANDS UNIV LIMBURG HOSP,DEPT SURG NL-6202 AZ MAASTRICHT NETHERLANDS
Titolo Testata:
Transplant international
fascicolo: 4, volume: 9, anno: 1996,
pagine: 396 - 402
SICI:
0934-0874(1996)9:4<396:ROPICW>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORGAN PRESERVATION; RENAL PRESERVATION; TRANSPLANTATION;
Keywords:
KIDNEY, PRESERVATION, RETROGRADE OXYGEN; ADENOSINE, KIDNEY, PRESERVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
M. Yin et al., "RETROGRADE OXYGEN PERSUFFLATION IN COMBINATION WITH UW SOLUTION ENHANCES ADENINE-NUCLEOTIDE CONTENTS IN ISCHEMICALLY DAMAGED RAT-KIDNEY DURING COLD-STORAGE", Transplant international, 9(4), 1996, pp. 396-402

Abstract

Retrograde oxygen persufflation (ROP) has been reported to be beneficial to kidney preservation. The purpose of this study was to investigate whether use of ROP during cold storage (CS) with Universita of Wisconsin (UW) solution could ameliorate energy metabolism and functional recovery of ischemically injured rat kidneys and, moreover, to study the particular role of adenosine (ADO) in CS with ROP. Kidneys subjected to 30 min of warm ischemia (WI) were preserved for 24 h in 4 degreesC UW solution with or without ROP and with or without ADO. Measurements of tissue high-energy phosphate levels showed that reduced total adenine nucleotides (TAN) after 30 min of WI further declined during thesubsequent CS. In ROP kidneys, however, TAN were less reduced, suggesting that even during CS, TAN can still be regenerated in the injured kidneys when ROP is combined with UW solution. When UW did not containADO, regeneration of TAN by ROP was slightly less than in the case ofUW with ADO. This indicates that the supply of molecular oxygen is a significant factor in TAN resynthesis during CS. There was no statistically significant difference in survival rate between the ROP and CS groups, indicating that an improved energy status is not the sole determinant of functional recovery. We conclude that the gaseous oxygen supply provided by ROP during CS in UW solution ameliorates the energy state of ischemically injured rat kidneys and that exogenous ADO from the UW solution contributes to the improvement of energy metabolism to alimited extent.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:31:29