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Titolo:
EVALUATION OF SURFACTANT TREATMENT STRATEGIES AFTER PROLONGED GRAFT STORAGE IN LUNG TRANSPLANTATION
Autore:
NOVICK RJ; MACDONALD J; VELDHUIZEN RAW; WAN F; DUPLAN J; DENNING L; POSSMAYER F; GILPIN AA; YAO LJ; BJARNESON D; LEWIS JF;
Indirizzi:
UNIV HOSP,DIV CARDIOVASC THORAC SURG,POB 5339 LONDON ON N6A 5A5 CANADA ROBARTS RES INST,TRANSPLANTAT IMMUNOBIOL GRP LONDON ON N6A 5C1 CANADA UNIV WESTERN ONTARIO,MRC,GRP FETAL & NEONATAL HLTH & DEV,DEPT BIOCHEMLONDON ON CANADA UNIV WESTERN ONTARIO,MRC,GRP FETAL & NEONATAL HLTH & DEV,DEPT OBSTET & GYNECOL LONDON ON CANADA ST JOSEPHS HLTH CTR,LAWSON RES INST LONDON ON CANADA ST JOSEPHS HLTH CTR,DIV RESP MED LONDON ON CANADA BLES BIOCHEM INC LONDON ON CANADA
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 1, volume: 154, anno: 1996,
pagine: 98 - 104
SICI:
1073-449X(1996)154:1<98:EOSTSA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; INSTILLED EXOGENOUS SURFACTANT; PULMONARY TRANSPLANTATION; REPLACEMENT THERAPY; PRESERVATION; PROCUREMENT; INJURY; DYSFUNCTION; SELECTION; HEART;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Novick et al., "EVALUATION OF SURFACTANT TREATMENT STRATEGIES AFTER PROLONGED GRAFT STORAGE IN LUNG TRANSPLANTATION", American journal of respiratory and critical care medicine, 154(1), 1996, pp. 98-104

Abstract

We have previously documented alterations in endogenous surfactant after lung transplantation and improved graft function in some dogs after instillation of bovine lipid extract surfactant (bLES) into the recipient. To determine the effect of bLES delivery method and timing of treatment on physiologic response and surfactant recovery, 21 canine left lung grafts were divided into four groups: (1) Treatment of the donor for 3 h with aerosolized bLES prior to graft storage (Donor Aerosol); (2) Treatment of the recipient with instilled bLES immediately after transplantation (Recipient Instilled); (3) No bLES treatment (Control); and (4) Aerosolized bLES in donors and instilled bLES in recipients (Combined Therapy). Aerosolized bLES was labeled with [H-3]-dipalmitoylphosphatidylcholine (DPPC) and instilled bLES with [C-14]-DPPC. Grafts were stored for 36 h, transplanted and reperfused for 6 h. The native right and transplanted left lungs were then lavaged and protein yield, surfactant aggregates, and bLES recovery were measured. After 6 hof reperfusion, PO2/FlO(2) ratio was significantly better after Combined Therapy (372 +/- 52 mm Hg) than in the Recipient Instilled (117 +/- 47 mm Hg) and Control groups (87 +/- 26 mm Hg), with intermediate values in Donor Aerosol dogs (232 +/- 64 mm Hg). The recovery of donor aerosolized bLES from transplanted lungs was increased in dogs given Combined Therapy versus Donor Aerosol treatment alone (p = 0.03). Furthermore, with Combined Therapy there was an increased percentage of instilled bLES recovered from transplanted lungs compared with the Recipient Instilled group. We conclude that surfactant treatment strategies influence physiologic response and bLES recovery after prolonged lung preservation. Treatment of lung donors with exogenous surfactant prior to graft storage was associated with less severe lung injury. Combineddonor and recipient bLES therapy resulted in a superior physiologic response during reperfusion in this model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 15:16:08