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Titolo:
NEW INSIGHTS INTO TUMOR-HOST INTERACTIONS IN LYMPHOMA METASTASIS
Autore:
UMANSKY V; SCHIRRMACHER V; ROCHA M;
Indirizzi:
GERMAN CANC RES CTR,DIV CELLULAR IMMUNOL,TUMOR IMMUNOL PROGRAM,NEUENHEIMER FELD 280 D-69120 HEIDELBERG GERMANY
Titolo Testata:
Journal of molecular medicine
fascicolo: 7, volume: 74, anno: 1996,
pagine: 353 - 363
SICI:
0946-2716(1996)74:7<353:NIITII>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; FUNCTION-ASSOCIATED ANTIGEN-1; INTERCELLULAR-ADHESION MOLECULE-1; SHEEP ERYTHROCYTE RECEPTOR; ACID-BINDING-RECEPTOR; NITRIC-OXIDE; ENDOTHELIAL-CELLS; KUPFFER CELLS; RAT-LIVER; CLASS-II;
Keywords:
METASTASIS; TUMOR MICROENVIRONMENT; COSTIMULATORY AND ADHESION MOLECULES; NITRIC OXIDE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
122
Recensione:
Indirizzi per estratti:
Citazione:
V. Umansky et al., "NEW INSIGHTS INTO TUMOR-HOST INTERACTIONS IN LYMPHOMA METASTASIS", Journal of molecular medicine, 74(7), 1996, pp. 353-363

Abstract

The metastatic process is characterized by a complex series of sequential steps involving constant interactions (mutual ''cross-talks'') ofmetastasized tumor cells with their microenvironment (lymphocyte, macrophages, endothelial cells, etc.) in target organs. These in teractions determine the outcome of metastasis (either the eradication of metastatic cells or their increased proliferation and invasion). Recently developed methods of tumor and host cell analysis at the molecular level allow better elucidation of molecular mechanisms of metastasis and of immune mechanisms involved in antitumor responses. Direct modulation of these processes will probably increase the success of clinical cancer treatment. Here we review data (a) on the expression of some costimulatory (MHC class II, CD80, sialoadhesin) and adhesion (LFA-1, ICAM-1, VLA-4) molecules on both metastasized tu mor cells and host cells and (b) on the production of a cytotoxic molecule, nitric oxide, by insitu activated Kupffer and endothelial cells in the process of liver metastasis. This study was performed with well-characterized murine ESbL T lymphoma cells transduced with the bacterial lacZ gene, which allows detection and quantification of metastases at the single cell level throughout lymphoma growth and metastasis. Experimental results are discussed in the context of recent literature.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:02:56