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Titolo:
TRANSCRIPTION, ADIPOCYTE DIFFERENTIATION, AND OBESITY
Autore:
AUWERX J; MARTIN G; GUERREMILLO M; STAELS B;
Indirizzi:
INST PASTEUR,INSERM,U325,DEPT ATHEROSCLEROSE,1 RUE CALMETTE F-59019 LILLE FRANCE INST BIOMED CORDELIERS,INSERM,U177 F-75006 PARIS FRANCE
Titolo Testata:
Journal of molecular medicine
fascicolo: 7, volume: 74, anno: 1996,
pagine: 347 - 352
SICI:
0946-2716(1996)74:7<347:TADAO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING-PROTEIN-ALPHA; GENE-EXPRESSION; PEROXISOME PROLIFERATOR; ACTIVATED RECEPTOR; FATTY-ACIDS; 3T3-L1 PREADIPOCYTES; TRANSGENIC MICE; ENHANCER; PROMOTER; C/EBP;
Keywords:
ADIPOCYTES; CCAATT ENHANCER BINDING PROTEIN; GENE EXPRESSION; NUCLEAR RECEPTORS; PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
78
Recensione:
Indirizzi per estratti:
Citazione:
J. Auwerx et al., "TRANSCRIPTION, ADIPOCYTE DIFFERENTIATION, AND OBESITY", Journal of molecular medicine, 74(7), 1996, pp. 347-352

Abstract

Differentiation of adipogenic precursor cells into mature adipocytes is a complex phenomenon, characterized by an ordered expression of adipocyte-specific genes, triggered by a set of interacting transcriptionfactors. The most important transcription factors involved in this process are the gamma form of peroxisome proliferator activated receptors (PPAR gamma) and the various members of the CCAAT enhancer binding proteins (alpha, beta, and delta). In addition to PPAR gamma and these enhancer binding proteins, several other transcription factors, including ADD-1 (SRE-BP), HMGI-C, are involved in regulating this process. Altered activity and/or expression of these transcription factors, willinduce the expression of target genes in the differentiating cells, ultimately resulting in the phenotypical characteristics of the adipocytes. It is speculated that modulation of these transcription factors by either pharmacological or dietary manipulations might influence adipocyte differentiation and prove beneficial in the prevention and treatment of obesity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:53:55