Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DIFFERENTIAL-EFFECTS OF A NEW AMPHOTERICIN-B DERIVATIVE, MS-8209, ON MOUSE BSE AND SCRAPIE - IMPLICATIONS FOR THE MECHANISM OF ACTION OF POLYENE ANTIBIOTICS
Autore:
ADJOU KT; DEMAIMAY R; LASMEZAS CI; SEMAN M; DESLYS JP; DORMONT D;
Indirizzi:
CEA,DEPT RECH MED,SERV NEUROVIROL,BP 6 FONTENAY ROSES FRANCE UNIV PARIS 07,INST JACQUES MONOD,LAB IMMUNODIFFERENCIAT F-75251 PARISFRANCE
Titolo Testata:
Research in virology
fascicolo: 4, volume: 147, anno: 1996,
pagine: 213 - 218
SICI:
0923-2516(1996)147:4<213:DOANAD>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN; PRION; ACCUMULATION; REPLICATION; INFECTION; HAMSTER; AGENT;
Keywords:
BSE, SCRAPIE, PRION, AMPHOTERICIN B; MS-8209 DERIVATIVE, POLYENE ANTIBIOTICS, MECHANISM OF ACTION, MOUSE, PRP, PRP-RES, GFAP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
K.T. Adjou et al., "DIFFERENTIAL-EFFECTS OF A NEW AMPHOTERICIN-B DERIVATIVE, MS-8209, ON MOUSE BSE AND SCRAPIE - IMPLICATIONS FOR THE MECHANISM OF ACTION OF POLYENE ANTIBIOTICS", Research in virology, 147(4), 1996, pp. 213-218

Abstract

Mice were infected intracerebrally with the bovine spongiform encephalopathy (BSE) or the scrapie agent and treated during 8 weeks postinfection to test the protective effect of a new amphotericin B (AmB) derivative, MS-8209, in experimental transmissible spongiform encephalopathies. The results show that (i) the treatment prolonged the incubationperiod of both BSE-infected and scrapie-infected mice, (ii) MS-8209 and AmB were much more efficient in delaying the onset of scrapie than that of BSE, and (iii) a delay in PrP-res (proteinase K-resistant prion protein) and GFAP (glial fibrillary acidic protein) accumulation wasobserved in the brains of scrapie-infected mice, but was not significant in BSE-infected mice. The analysis of the molecular and clinical results strongly suggests a common mechanism of action of this categoryof drugs on the different transmissible spongiform encephalopathy strains. This could be due to an interaction with the PrP transconformation process leading to the formation of PrP-res.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:24:59