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Titolo:
EXPRESSION OF THE CELL DEATH-INDUCING GENE BAX IN CARCINOMAS DEVELOPED FROM THE FOLLICULAR CELLS OF THE THYROID-GLAND
Autore:
BRANET F; BROUSSET P; KRAJEWSKI S; SCHLAIFER D; SELVES J; REED JC; CARON P;
Indirizzi:
CHU PURPAN,ANAT PATHOL LAB,PL DR BAYLAC F-31059 TOULOUSE FRANCE CHU PURPAN,ANAT PATHOL LAB F-31059 TOULOUSE FRANCE CHU PURPAN,CNRS,CIGH F-31059 TOULOUSE FRANCE CHU RANGUEIL,SERV ENDOCRINOL TOULOUSE FRANCE LA JOLLA CANC RES FDN LA JOLLA CA 92037
Titolo Testata:
The Journal of clinical endocrinology and metabolism
fascicolo: 7, volume: 81, anno: 1996,
pagine: 2726 - 2730
SICI:
0021-972X(1996)81:7<2726:EOTCDG>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VIVO; IMMUNOHISTOCHEMICAL ANALYSIS; BCL-X; C-MYC; PROTEIN; TISSUES; P53; TRANSLOCATION; APOPTOSIS; REGULATOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
F. Branet et al., "EXPRESSION OF THE CELL DEATH-INDUCING GENE BAX IN CARCINOMAS DEVELOPED FROM THE FOLLICULAR CELLS OF THE THYROID-GLAND", The Journal of clinical endocrinology and metabolism, 81(7), 1996, pp. 2726-2730

Abstract

The expression of apoptosis-regulating proteins, Bcl-2, Bax, Mcl-1, and Bcl-X, was evaluated by immunohistochemical methods in 39 cases of thyroid carcinomas. Normal thyroid tissues showed a consistent expression of Bcl-2 and Mcl-1 whereas Bax and Bcl-X proteins were essentiallyabsent from most follicular thyroid cells. Bax expression was observed in all papillary carcinomas (n = 23) and in 8 of 10 follicular carcinomas. The intensity of Bcl-2 immunostaining was generally higher in follicular tumors (n = 10) than in papillary carcinomas (n = 21 of 23). However, in undifferentiated tumors, both Bax and Bcl-2 were weakly expressed. Mcl-1 protein expression was similar to that of Bax in papillary and follicular tumors, but was also frequently detectable in undifferentiated tumors. Bcl-X immunostaining was seen in all undifferentiated tumors (n = 6), in 22 of 23 papillary tumors, and in 5 of 10 follicular tumors. Our findings show that the regulation of bcl-2 family gene expression is different in normal thyroid tissue compared to that of its neoplastic counterpart and varies with the tumor subtype. In particular, unlike normal thyroid epithelium, the apoptosis-blocking gene bcl-X and the apoptosis-inducing gene bar are frequently expressed in thyroid carcinomas derived from the follicular cells. Thus, alterations in the expression of these bcl-2 family genes may contribute to the pathogenesis of thyroid carcinomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:44:55