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Titolo:
DYNAMIC CHANGES IN STRIATAL DOPAMINE D-2 AND D-3 RECEPTOR PROTEIN ANDMESSENGER-RNA IN RESPONSE TO 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) DENERVATION IN BABOONS
Autore:
TODD RD; CARL J; HARMON S; OMALLEY KL; PERLMUTTER JS;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT,4940 CHILDRENS PL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT GENET ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT ANAT & NEUROBIOL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT NEUROL & NEUROSURG ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,MALLINCKRODT INST RADIOL ST LOUIS MO 63110
Titolo Testata:
The Journal of neuroscience
fascicolo: 23, volume: 16, anno: 1996,
pagine: 7776 - 7782
SICI:
0270-6474(1996)16:23<7776:DCISDD>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALTERNATIVE TRANSCRIPTS; RAT; EXPRESSION; PARKINSONISM; MONKEYS; GENE; LESIONS; BRAIN; MOUSE; HEMIPARKINSONISM;
Keywords:
PARKINSONS DISEASE; MPTP; DOPAMINE D-2 RECEPTOR; DOPAMINE D-3 RECEPTOR; CAUDATE; PUTAMEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
R.D. Todd et al., "DYNAMIC CHANGES IN STRIATAL DOPAMINE D-2 AND D-3 RECEPTOR PROTEIN ANDMESSENGER-RNA IN RESPONSE TO 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) DENERVATION IN BABOONS", The Journal of neuroscience, 16(23), 1996, pp. 7776-7782

Abstract

Loss of nigrostriatal neurons leads to striatal dopamine deficiency and subsequent development of parkinsonism. The effects of this denervation on D-2-like receptors in striatum remain unclear. Most studies have demonstrated increases in striatal dopamine D-2-like receptors in response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated denervation, but others have found either decreases or no change in binding. To clarify the response to denervation, we have investigated the time-dependent changes in dopamine D-2, D-3, and D-4 receptor protein and mRNA levels in unilaterally MPTP-lesioned baboons. MPTP (0.4 mg/kg) was infused into one internal carotid artery, producing a contralateral hemi-parkinsonian syndrome. After MPTP treatment, the animals were maintained for 17-480 d and then euthanized. MPTP decreased ipsilateral dopamine content by >90%, which did not change with time. Ipsilateral D-2-like receptor binding in caudate and putamen initially decreased then increased two- to sevenfold over the first 100 d and returned to near baseline levels by 480 d. Relative levels of D-2 mRNA were essentially unchanged over this period. D-4 mRNA was not detected. In contrast, D-3 mRNA increased sixfold by 2 weeks and then decreased. Atthe peak period of increase in binding sites, all D-2-like receptors were in a micromolar affinity agonist-binding state, implying an increase in uncoupled D-2 but not D-3 receptor protein. Taken together, these data suggest that MPTP-induced changes in D-2-like dopamine receptors are complex and include translational or post-translational mechanisms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 18:24:25