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Titolo:
EFFECTS OF BINGE PATTERN COCAINE ADMINISTRATION ON DOPAMINE D-1 AND D-2 RECEPTORS IN THE RAT-BRAIN - AN IN-VIVO STUDY USING POSITRON EMISSION TOMOGRAPHY
Autore:
TSUKADA H; KREUTER J; MAGGOS CE; UNTERWALD EM; KAKIUCHI T; NISHIYAMA S; FUTATSUBASHI M; KREEK MJ;
Indirizzi:
HAMAMATSU PHOTON KK,CENT RES LAB,500 HIRAKUCHI HAMAKITA SHIZUOKA 434 JAPAN ROCKEFELLER UNIV,LAB BIOL ADDICT DIS NEW YORK NY 10021 NYU,MED CTR,DEPT PSYCHIAT NEW YORK NY 10003
Titolo Testata:
The Journal of neuroscience
fascicolo: 23, volume: 16, anno: 1996,
pagine: 7670 - 7677
SICI:
0270-6474(1996)16:23<7670:EOBPCA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED BEHAVIORAL SENSITIZATION; H-3 N-METHYLSPIPERONE; NUCLEUS ACCUMBENS; INVIVO BINDING; EXTRACELLULAR DOPAMINE; RACLOPRIDE BINDING; STRIATUM; MICRODIALYSIS; AMPHETAMINE; EXPRESSION;
Keywords:
COCAINE; DOPAMINE RECEPTORS; [C-11] SCH23390; [C-11] N-METHYLSPIPERONE; POSITRON EMISSION TOMOGRAPHY; RAT BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
H. Tsukada et al., "EFFECTS OF BINGE PATTERN COCAINE ADMINISTRATION ON DOPAMINE D-1 AND D-2 RECEPTORS IN THE RAT-BRAIN - AN IN-VIVO STUDY USING POSITRON EMISSION TOMOGRAPHY", The Journal of neuroscience, 16(23), 1996, pp. 7670-7677

Abstract

The aim of the present study was to determine the effect of ''binge''pattern cocaine administration on dopamine D-1 and D-2 receptors in the rat brain. Male Sprague Dawley rats were injected three times at 1 hr intervals with saline or cocaine (15 mg/kg) each day for 2, 7, or 14 d. The in vivo binding of [C-11]SCH23390 (dopamine D-1 receptor antagonist) and [C-11]N-methylspiperone (NMSP; dopamine D-2 receptor antagonist) in the striatal region was measured by a high-resolution positron emission tomography at 1 and 3.5 hr, respectively, after the last cocaine or saline injection. Acute (2 d) binge cocaine administration did not change the in vivo binding potential of [C-11]SCH23390 or the binding of [C-11]NMSP in the striatum. After 7 d of binge cocaine administration, a significant decrease in the binding potential of [C-11]SCH23390 was observed, whereas no change in the binding of [C-11]NMSP was found. After 14 d of binge cocaine administration, the in vivo binding was significantly reduced for both [C-11]SCH23390 and [C-11]NMSP. Separate saturation experiments indicated that the observed alterationsof in vivo binding were attributable mainly to apparent alterations in the affinity and not the number of binding sites. These results suggest that both dopamine D-1 and D-2 receptors may have altered physiologically available binding sites after binge pattern cocaine administration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:41:36