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Titolo:
HAPLOIDENTICAL BONE-MARROW TRANSPLANTS FOR 2 PATIENTS WITH RETICULAR DYSGENESIS
Autore:
DESANTES KB; LAI SS; COWAN MJ;
Indirizzi:
UNIV CALIF SAN FRANCISCO,DEPT PEDIAT,DIV BONE MARROW TRANSPLANTAT SANFRANCISCO CA 94143
Titolo Testata:
Bone marrow transplantation
fascicolo: 6, volume: 17, anno: 1996,
pagine: 1171 - 1173
SICI:
0268-3369(1996)17:6<1171:HBTF2P>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE COMBINED IMMUNODEFICIENCY; COLONY-STIMULATING FACTOR; DISEASE;
Keywords:
RETICULAR DYSGENESIS; BMT; MISMATCH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
K.B. Desantes et al., "HAPLOIDENTICAL BONE-MARROW TRANSPLANTS FOR 2 PATIENTS WITH RETICULAR DYSGENESIS", Bone marrow transplantation, 17(6), 1996, pp. 1171-1173

Abstract

We report two cases of reticular dysgenesis (RD) successfully treatedby BMT utilizing T cell-depleted haploidentical marrow grafts. One child failed to engraft after conditioning with ATG, and the other failed two transplant attempts with cyclophosphamide + ATG, and busulfan + cyclophosphamide + ATG, respectively. Donor engraftment was achieved in both patients following treatment with 700 cGy TBI, with or without other agents. These results, taken together with previous reports in the literature, suggest that children with RD may require more intensive conditioning than patients with other types of severe combined immunodeficiency syndrome.

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Documento generato il 11/08/20 alle ore 15:42:50