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Titolo:
INTELLECTUAL-DEVELOPMENT OF THE PATIENTS OF THE GERMAN COLLABORATIVE STUDY OF CHILDREN TREATED FOR PHENYLKETONURIA
Autore:
BURGARD P; SCHMIDT E; RUPP A; SCHNEIDER W; BREMER HJ;
Indirizzi:
UNIV HEIDELBERG,DEPT GEN PEDIAT,GERMAN COLLABORAT STUDY PHENYLKETONURIA,NEUENHEIMER FELD 150 D-69120 HEIDELBERG GERMANY UNIV WURZBURG,DEPT PSYCHOL D-97074 WURZBURG GERMANY
Titolo Testata:
European journal of pediatrics
, volume: 155, anno: 1996, supplemento:, 1
pagine: 33 - 38
SICI:
0340-6199(1996)155:<33:IOTPOT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIETARY-TREATMENT; IQ; PHENYLALANINE; INTELLIGENCE;
Keywords:
PHENYLKETONURIA; DIETARY TREATMENT; PHENYLALANINE RECOMMENDATIONS; INTELLIGENCE DEVELOPMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
P. Burgard et al., "INTELLECTUAL-DEVELOPMENT OF THE PATIENTS OF THE GERMAN COLLABORATIVE STUDY OF CHILDREN TREATED FOR PHENYLKETONURIA", European journal of pediatrics, 155, 1996, pp. 33-38

Abstract

In a multicentric and interdisciplinary approach the German Collaborative Study of Children Treated for Phenylketonuria (PKU) investigates prospectively the effects of early started strict dietary treatment onthe growth and development of 140 patients. The present paper focuseson longitudinal intelligence data from 4, 5 and 9 years of age of 89 patients in relation to the quality of dietary control in comparison to 200 healthy children tested by the same protocol. Cluster analysis of phenylalanine (Phe) levels distinguished a cluster of good dietary control with Phe levels according to the recommendation of maintaining Phe levels below 360 mu mol/l, a cluster of poor dietary control with Phe levels greater than 600 mu mol/l after the age of 3 years, and a cluster of intermediate control. Intelligence quotients (IQ) and Phe clusters were inversely related with non-significant differences betweenthe clusters good and intermediate. On average, all three clusters scored significantly lower than healthy age peers. Mean IQ scores decreased for patients as well as for healthy children due to different tests used at different measurement occasions. Patients with poor dietary control showed a steeper decrease between 4 and 5 years than patients with better dietary control. Between 5 and 9 years IQ differences between patients and healthy children remained stable. Verbal IQs were higher than performance IQs for patients as well as for healthy children. It is concluded that after early and strict treatment during the pre-school years Phe levels, in the range observed, do not influence IQ development until the age of 9 years. IQ subscale pattern indicate that PKU results in a generalized reduction of IQ instead of disturbing specific abilities. It remains to be investigated whether higher Phe levels are also innocuous and/or may result in late effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:06:58