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Titolo:
SCANNING ELECTRON-MICROSCOPY SHOWS INHIBITED GUBERNACULAR DEVELOPMENTIN RELATION TO UNDESCENDED TESTES IN ESTROGEN-TREATED MICE
Autore:
SHONO T; HUTSON JM; WATTS L; GOH DW; MOMOSE Y; MIDDLESWORTH B; ZHOU B; RAMMANDERSON S;
Indirizzi:
ROYAL CHILDRENS HOSP,DEPT GEN SURG,SURG RES UNIT,FLEMINGTON RD PARKVILLE VIC 3052 AUSTRALIA ROYAL CHILDRENS HOSP,DEPT GEN SURG,SURG RES UNIT PARKVILLE VIC 3052 AUSTRALIA UNIV MELBOURNE,DEPT ANAT MELBOURNE FL 00000
Titolo Testata:
International journal of andrology
fascicolo: 5, volume: 19, anno: 1996,
pagine: 263 - 270
SICI:
0105-6263(1996)19:5<263:SESIGD>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULLERIAN DUCT SYNDROME; TESTICULAR DESCENT; HORMONAL-REGULATION; 1ST PHASE; FLUTAMIDE; RAT; MODEL; CRYPTORCHIDISM; FEMINIZATION; PERSISTENCE;
Keywords:
GUBERNACULUM; TRANSABDOMINAL TESTICULAR DESCENT; SCANNING EM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
T. Shono et al., "SCANNING ELECTRON-MICROSCOPY SHOWS INHIBITED GUBERNACULAR DEVELOPMENTIN RELATION TO UNDESCENDED TESTES IN ESTROGEN-TREATED MICE", International journal of andrology, 19(5), 1996, pp. 263-270

Abstract

The morphological relationship between transabdominal testicular descent and the 'swelling reaction' of the gubernaculum was investigated in oestrogen-treated fetal mice by using scanning electron microscopy (scanning EM). In addition, flutamide was also administered to pregnantmice to determine whether androgens cause gubernacular growth and transabdominal testicular descent in offspring. In oestrogen-treated treated fetal mice, scanning EM showed that both the gubernacular 'swelling reaction' and transabdominal testicular descent were inhibited, in addition to inhibition of Mullerian duct regression. The gubernaculum showed a nat, thin bulb (widest diameter 0.25 +/- 0.04 mm) and an elongated cord (1.28 +/- 0.41 mm) after oestrogen treatment in utero, whichwas significantly different in appearance from that in normal controlmice (width 0.44 mm +/- 0.06 mm, p < 0.001; length 0.27 +/- 0.19 mm, p < 0.0001). However, flutamide-treated mice showed much more normal gubernacular enlargement and transabdominal testicular descent. The width of the gubernacular bulb after flutamide exposure was 0.44 +/- 0.05mm, which was comparable to that in control animals; the length of the intra-abdominal gubernaculum (0.44 +/- 0.15 mm) was slightly longer than in controls (p < 0.02). These results suggest that both the swelling reaction of the gubernaculum and transabdominal testicular migration are blocked by prenatal exposure to oestrogen. However, oestrogen exposure of the fetus does not block the swelling reaction of the gubernaculum by acting as an antiandrogen.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:26:01