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Titolo:
BETA(2)-RECEPTOR DENSITY ON MONONUCLEAR BLOOD-CELLS IN PATIENTS SUFFERING FROM NEUROLEPTIC-INDUCED AKATHISIA (NIA)
Autore:
BOTSCHEV C; BONDY B; HOFMANN M; KIRCHER T; MULLERSPAHN F;
Indirizzi:
UNIV MUNICH,HOSP PSYCHIAT,NUSSBAUMSTR 7 D-80336 MUNICH GERMANY
Titolo Testata:
Biological psychiatry
fascicolo: 3, volume: 40, anno: 1996,
pagine: 203 - 207
SICI:
0006-3223(1996)40:3<203:BDOMBI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID; SCHIZOPHRENIA;
Keywords:
NEUROLEPTIC-INDUCED AKATHISIA; BETA(2)-RECEPTOR DENSITY; MONONUCLEAR CELLS; TREATMENT WITH PROPRANOLOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
C. Botschev et al., "BETA(2)-RECEPTOR DENSITY ON MONONUCLEAR BLOOD-CELLS IN PATIENTS SUFFERING FROM NEUROLEPTIC-INDUCED AKATHISIA (NIA)", Biological psychiatry, 40(3), 1996, pp. 203-207

Abstract

The effectiveness of beta-blockers in the treatment of neuroleptic-induced akathisia (NIA) suggests that beta-adrenergic overactivity is involved in the manifestation of NIA. As an approach to understanding this postulated overactivity, we investigated the beta(2)-receptor density on mononuclear blood cells in 21 patients suffering from NIA as well as in 12 patients without NIA. The beta(2)-receptor density in NIA-positive patients was significantly higer than that in NIA-negative patients (t = 2.84; p = .008). The NIA-positive patients were treated with 20 mg propranolol t.i.d. for 5 days, The beta(2)-receptor density intreatment responders did not differ significantly from that in non-responders. Our results indicate that beta(2)-receptors on mononuclear cells in patients with NIA may be of a certain degree of importance. With the prerequisites of replicability as well as correlation of this parameter with therapeutic success of beta-blockers, it may be considered as a predictor for treatment response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:16:02