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Titolo:
PHARMACOKINETICS OF CEFIXIME IN CHILDREN WITH URINARY-TRACT INFECTIONS AFTER A SINGLE ORAL DOSE
Autore:
MAMZORIDI K; KASTERIDOU N; PEONIDES A; NIOPAS I;
Indirizzi:
ARISTOTELIAN UNIV THESSALONIKI,DEPT PHARM GR-54006 THESSALONIKI GREECE ARISTOTELIAN UNIV THESSALONIKI,DEPT PHARM GR-54006 THESSALONIKI GREECE ARISTOTELIAN UNIV THESSALONIKI,SCH MED,ACHEPA HOSP,PAEDIAT CLIN 4 GR-54006 THESSALONIKI GREECE
Titolo Testata:
Pharmacology & toxicology
fascicolo: 6, volume: 78, anno: 1996,
pagine: 417 - 420
SICI:
0901-9928(1996)78:6<417:POCICW>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIMICROBIAL THERAPY; PROFILE; INFANTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
K. Mamzoridi et al., "PHARMACOKINETICS OF CEFIXIME IN CHILDREN WITH URINARY-TRACT INFECTIONS AFTER A SINGLE ORAL DOSE", Pharmacology & toxicology, 78(6), 1996, pp. 417-420

Abstract

The pharmacokinetics of cefixime. a third-generation broad-spectrum cephalosporin, were determined following administration of a 8 mg/kg single oral dose of cefixime suspension to six children with urinary tract infections, ages from 6 to 13 years and weights from 17 to 60 kg. Blood samples for determination of plasma cefixime concentrations were obtained for up to 12 hr and complete urine collections were obtained for urinary excretion of unchanged parent drug for up to 24 hr after administration. Plasma and urine concentrations of cefixime were determined using a reversed phase HPLC assay and pertinent pharmacokinetic parameters were estimated by model-independent standard methods. Mean peak plasma concentration was 4.04 mu g/ml and was reached after 3.2 hr. The mean area under the plasma concentration time curve was 33.07 mug.hr/ml and the mean elimination half-life was 3.91 hr. The mean apparent total clearance was 4.74 ml/min./kg and about 15% of the dose administered was recovered unchanged in urine. In conclusion, the estimated pharmacokinetic values of cefixime were comparable to those observed in healthy adult subjects based on equivalent mg/kg doses. Plasma and urine concentrations of the drug were well above the reported minimal plasma and urinary concentrations for most common urinary tract pathogens for up to 12 and 24 hr after administration, respectively.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 07:12:11