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Titolo:
COMPARISON OF THE EFFECTS OF 2 CHOLECYSTOKININ-RECEPTOR ANTAGONISTS, LOXIGLUMIDE AND L-364,718, ON THE PANCREATIC SECRETORY RESPONSE TO INTRADUODENAL TRYPTOPHAN IN DOGS
Autore:
NIEBERGALLROTH E; TEYSSEN S; WETZEL D; HARTEL M; BEGLINGER C; RIEPL RL; SINGER MV;
Indirizzi:
UNIV HEIDELBERG HOSP,DEPT MED GASTROENTEROL 4,THEODOR KUTZER UFER D-68135 MANNHEIM GERMANY UNIV HEIDELBERG HOSP,DEPT MED GASTROENTEROL 4 D-68135 MANNHEIM GERMANY UNIV HEIDELBERG HOSP,DEPT SURG D-68135 MANNHEIM GERMANY UNIV MUNICH,KLINIKUM INNENSTADT D-8000 MUNICH GERMANY UNIV BASEL HOSP,DIV GASTROENTEROL CH-4031 BASEL SWITZERLAND
Titolo Testata:
Scandinavian journal of gastroenterology
fascicolo: 7, volume: 31, anno: 1996,
pagine: 723 - 732
SICI:
0036-5521(1996)31:7<723:COTEO2>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG; CCK; RAT; EXPRESSION; ATROPINE; CLONING; RELEASE; POTENT;
Keywords:
CHOLECYSTOKININ; CHOLECYSTOKININ RECEPTOR; DOG; LOXIGLUMIDE; PANCREATIC SECRETION; L-364,718; L-TRYPTOPHAN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
E. Niebergallroth et al., "COMPARISON OF THE EFFECTS OF 2 CHOLECYSTOKININ-RECEPTOR ANTAGONISTS, LOXIGLUMIDE AND L-364,718, ON THE PANCREATIC SECRETORY RESPONSE TO INTRADUODENAL TRYPTOPHAN IN DOGS", Scandinavian journal of gastroenterology, 31(7), 1996, pp. 723-732

Abstract

Background: The aim of the study was to compare the effects of the cholecystokinin (CCK)-receptor antagonists loxiglumide and L-364,718 on the endogenously stimulated pancreatic exocrine secretion. Methods: Insix conscious dogs with chronic gastric and pancreatic fistulas we compared the action of different doses of loxiglumide (7.5 to 10.0 mg/kg/h) and L-364,718 (0.025 to 0.1 mg/kg/h) on the pancreatic secretory response to intraduodenal perfusion of graded loads of tryptophan (0.37-10.0 mmol/h), given against a background of secretin (20.5 pmol/kg/h intravenously). Results: both loxiglumide and L-364,718 inhibited the secretin-stimulated pancreatic bicarbonate output by up to 47% and 48%, respectively. The pancreatic protein output during secretin was significantly inhibited by all doses of L-364,718 (by 65% to 82%) but not by loxiglumide. All doses of loxiglumide and L-364,718 abolished the 180-min integrated bicarbonate response to tryptophan. The two higher doses of loxiglumide (5.0-10.0 mg/kg/h) and L-364,718 (0.05-0.1 mg/kg/h) significantly decreased the 180-min integrated response to tryptophan by 59% and 79% (loxiglumide) and by 72% and 97% (L-364,718). The plasma CCK-like immunoreactivity basally and in response to tryptophan was nor significantly altered by loxiglumide or L-364,718. Conclusions: These findings indicate that in dogs 1) the pancreatic bicarbonate response to secretin is augmented by the hormone CCK; 2) L-364,718 but not loxiglumide decreases pancreatic protein output during secretin; 3) endogenous released CCK is involved in the pancreatic bicarbonate response and is a major mediator of pancreatic protein response to intraduodenal tryptophan; and 4) the release of CCK by intraduodenal tryptophan is not influenced by loxiglumide and L-364,718.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:07:16