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Titolo:
EFFECT OF EXTENSIVE DEBRIDEMENT AND TREATMENT ON THE HEALING OF DIABETIC FOOT ULCERS
Autore:
STEED DL; DONOHOE D; WEBSTER MW; LINDSLEY L; RICOTTA JJ; LUTERMAN A; BROWN S; COMEROTA AJ; WALSH DB; BERGAMINI TM; BAKER WH; BOLTAX RS; SCHWARCZ TH; DONOHOE DJ; FLEISHMAN A;
Indirizzi:
UNIV PITTSBURGH,MED CTR,PRESBYTERIAN UNIV HOSP,A1011 PITTSBURGH PA 15213 UNIV PITTSBURGH,DEPT SURG,WOUND HEALING LIMB PRESERVAT CLIN PITTSBURGH PA 00000 ROBERT WOOD JOHNSON PHARMACEUT RES INST RARITAN NJ 00000
Titolo Testata:
Journal of the American College of Surgeons
fascicolo: 1, volume: 183, anno: 1996,
pagine: 61 - 64
SICI:
1072-7515(1996)183:1<61:EOEDAT>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLATELET; WOUNDS; TRIAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
D.L. Steed et al., "EFFECT OF EXTENSIVE DEBRIDEMENT AND TREATMENT ON THE HEALING OF DIABETIC FOOT ULCERS", Journal of the American College of Surgeons, 183(1), 1996, pp. 61-64

Abstract

BACKGROUND: There has been a broad interest in the use of growth factors to treat patients with chronic nonischemic diabetic ulcers. STUDY DESIGN: One hundred eighteen patients were studied in a randomized, prospective, double-blind, multicenter trial comparing treatment with topically applied recombinant human platelet-derived growth factor (rhPDGF) or placebo (vehicle) and were treated until completely healed or to 20 weeks. All patients had aggressive sharp debridement of their ulcers before randomization and repeat debridement of callus and necrotictissue as needed. The influence of debridement was evaluated by reviewing the records of the office visits where debridement was performed. RESULTS. Forty-eight percent of patients treated with rhPDGF healed compared with 25 percent of patients who received placebo (p=0.01). Themean percentage of office visits where debridement was performed was comparable for the two treatment groups: 46.8 percent (rhPDGF) and 48.0 percent (placebo). In general, a lower rate of healing was observed in those centers that performed less frequent debridement. The improved response rate observed with more frequent debridement was independent of the treatment group. However, for any given center, the percentage of patients who healed was greater with rhPDGF than placebo. CONCLUSIONS: Wound debridement is a vital adjunct in the care of patients with chronic diabetic foot ulcers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/08/20 alle ore 01:43:00