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Titolo:
TO WHAT EXTENT DO SPINAL INTERACTIONS BETWEEN AN ALPHA-2-ADRENOCEPTORAGONIST AND A MU-OPIOID AGONIST INFLUENCE NOXIOUSLY EVOKED C-FOS EXPRESSION IN THE RAT - A PHARMACOLOGICAL STUDY
Autore:
HONORE P; CHAPMAN V; BURITOVA J; BESSON JM;
Indirizzi:
INSERM,U161,2 RUE ALESIA F-75014 PARIS FRANCE
Titolo Testata:
The Journal of pharmacology and experimental therapeutics
fascicolo: 1, volume: 278, anno: 1996,
pagine: 393 - 403
SICI:
0022-3565(1996)278:1<393:TWEDSI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL HORN NEURONS; CENTRAL NERVOUS-SYSTEM; ALPHA-2-ADRENOCEPTOR AGONIST; ISOBOLOGRAPHIC ANALYSIS; NOCICEPTIVE RESPONSES; SELECTIVE-INHIBITION; MESSENGER-RNAS; BLOOD-PRESSURE; BINDING-SITES; FORMALIN TEST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
79
Recensione:
Indirizzi per estratti:
Citazione:
P. Honore et al., "TO WHAT EXTENT DO SPINAL INTERACTIONS BETWEEN AN ALPHA-2-ADRENOCEPTORAGONIST AND A MU-OPIOID AGONIST INFLUENCE NOXIOUSLY EVOKED C-FOS EXPRESSION IN THE RAT - A PHARMACOLOGICAL STUDY", The Journal of pharmacology and experimental therapeutics, 278(1), 1996, pp. 393-403

Abstract

Three hours after the intraplantar injection of carrageenin (6 mg/150mu l of saline) Fos-like immunoreactivity (Fos-LI) was observed in both superficial and deep laminae of the dorsal horn segments L4 and L5 of the spinal cord. Systemic medetomidine, an alpha-2 adrenoceptor agonist (12.5, 25 or 75 mu g/kg i.v.), dose-dependently reduced the number of superficial and deep Fos-LI neurons; 75 mu g/kg produced a 66 +/-4% and a 90 +/- 4% reduction of superficial and deep Fos-LI neurons, respectively, P < .0001 for both. In addition, systemic medetomidine dose-relatedly reduced the carrageenin-evoked paw and ankle edema; medetomidine 75 mu g/kg resulted in a 70 +/- 3% reduction of paw edema andin a blockade of the development of ankle edema. The effects of medetomidine were blocked by systemic atipamezole (75 mu g/kg, i.v.), which, when injected alone, had no effect on the number of Fos-LI neurons or the peripheral edema. Go-administration of a low dose of medetomidine (12.5 mu g/kg i.v.) with an ineffective dose of morphine (1.5 mg/kg i.v.) strongly decreased the number of superficial and deep Fos-LI neurons (40 +/- 5%, P < .0001 and 62 +/- 11%, P < .0001 reduction as compared with control group) without altering the effects of medetomidine on the peripheral edema. Both atipamezole and a combined injection of atipamezole and naloxone blocked the effects of medetomidine plus morphine on both the total number of Fos-LI neurons (86 +/- 11% and 86 +/-6% of control, respectively) and carrageenin inflammation (87 +/- 6%,P < .05 and 84 +/- 3%, P < .05 of control for the paw edema; 75 +/- 8%, P < .01 and 81 +/- 7%, P < .05 of control for the ankle edema, respectively). Naloxone alone blocked the effects of the co-administered agonists on the total number of Fos-LI neurons (91 +/- 6% of the control carrageenin group) without influencing the effect on the peripheral edema. Our results demonstrate, for the first time, that cc-administration of alpha-2 adrenoceptor and mu opioid agonists substantially reduces inflammatory evoked expression of c-Fos, one of the long-term consequences of sustained nociceptive processing.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 12:14:25