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Titolo:
ABSORPTION, TISSUE DISTRIBUTION, AND EXCRETION OF ZINC ACEXAMATE IN RATS
Autore:
WU JF; WANG MW; SONG LS; LIU ZF;
Indirizzi:
SHENZHEN NEPTUNUS PHARMACEUT CO LTD SHENZHEN 518052 PEOPLES R CHINA SHENYANG UNIV PHARM SHENYANG 110015 PEOPLES R CHINA NORMAN BETHUNE UNIV MED SCI CHANGCHUN 130021 PEOPLES R CHINA
Titolo Testata:
Zhongguo yaoli xuebao
fascicolo: 4, volume: 17, anno: 1996,
pagine: 375 - 378
SICI:
0253-9756(1996)17:4<375:ATDAEO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Keywords:
ZINC ACEXAMATE; ACEXAMIC ACID; INTESTINAL ABSORPTION; TISSUE DISTRIBUTION; PHARMACOKINETICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
4
Recensione:
Indirizzi per estratti:
Citazione:
J.F. Wu et al., "ABSORPTION, TISSUE DISTRIBUTION, AND EXCRETION OF ZINC ACEXAMATE IN RATS", Zhongguo yaoli xuebao, 17(4), 1996, pp. 375-378

Abstract

AIM: To study the pharmacokinetic character of zinc acexamate (ZA) inrats. METHODS: Determined [H-3]ZA after thin layer chromatography. RESULTS: After ig [H-3]ZA (2.07 MBq . kg(-1)), 70.3 % of the radioactivity in the urine, 16.3 % was excreted in the feces in 4 d. In the urineand feces, 57.1 % and 12.9 % of the dose, respectively, consisted of unchanged drug. After iv [H-3]ZA (4.66 MBq . kg(-1)), the blood concentration-time curve was shown to fit 2-compartment with T-1/2 alpha = 0.8 h and T-1/2 beta = 11.6 h. The bioavailability was about 52.8 %. After ig [H-3]ZA (4.44 MBq . kg(-1)), higher radioactivities were observed in kidney, liver, and gastrointestinal tract but lower in brain, fat, and femur. CONCLUSION: ZA given ig in rats was absorbed rapidly anddistributed widely to most of the organs and tissues.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 04:55:09