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Titolo:
EFFECT OF MATRINE ON LIPOPOLYSACCHARIDES D-GALACTOSAMINE-INDUCED HEPATITIS AND TUMOR-NECROSIS-FACTOR RELEASE FROM MACROPHAGES IN-VITRO/
Autore:
HU ZL; ZHANG JP; YU XB; LIN W; QIAN DH; WAN MB;
Indirizzi:
MIL MED COLL 2,COLL PHARM,RES LAB NAT & SYNTH DRUGS SHANGHAI 200433 PEOPLES R CHINA MIL MED COLL 2,CHANGHAI HOSP,DEPT INFECT DIS SHANGHAI 200433 PEOPLES R CHINA
Titolo Testata:
Zhongguo yaoli xuebao
fascicolo: 4, volume: 17, anno: 1996,
pagine: 351 -
SICI:
0253-9756(1996)17:4<351:EOMOLD>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICE;
Keywords:
MATRINE; TOXIC HEPATITIS; GALACTOSAMINE; LIPOPOLYSACCHARIDES; TUMOR NECROSIS FACTOR; PERITONEAL MACROPHAGES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
6
Recensione:
Indirizzi per estratti:
Citazione:
Z.L. Hu et al., "EFFECT OF MATRINE ON LIPOPOLYSACCHARIDES D-GALACTOSAMINE-INDUCED HEPATITIS AND TUMOR-NECROSIS-FACTOR RELEASE FROM MACROPHAGES IN-VITRO/", Zhongguo yaoli xuebao, 17(4), 1996, pp. 351

Abstract

To study the effects of matrine (Mat) on lipopolysaccharides (LPS)-induced fatal hepatitis in D-galactosamine (D-GalN)-sensitized mice and tumor necrosis factor (TNF) release from peritoneal macrophages (PMO). METHODS: Mice were pretreated with Mat (10, 50 mg . kg(-1), ip, bid x3 d), and then;injected ip LPS + D-GalN. Liver injury was assessed byquantifying plasma activity of alanine aminotransferase (ALT) and histopathological examination. The TNF activities in the; supernatants ofmouse PMO stimulated with LPS in the presence of Mat (32.5 - 500 mg . L(-1)) were monitored by the L929 target cells lytic assay. RESULTS: Mat pretreatment markedly diminished hepatic injury induced by LPS in combination with D-GalN. Mat inhibited LPS-induced TNF release from mouse PMO in vitro in a concentration-dependent manner. CONCLUSION: Mat protected the D-GalN-treated mice from the development of fatal hepatitis induced by LPS, and inhibited the LPS-induced TNF release from mouse PMO.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/02/20 alle ore 11:54:04