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Titolo:
CATABOLIC EFFECT IN PREMATURE-INFANTS WITH EARLY DEXAMETHASONE TREATMENT
Autore:
TSAI FJ; TSAI CH; WU SF; LIU YH; YEH TF;
Indirizzi:
CHINA MED COLL HOSP,DEPT PEDIAT,75 YUH DER RD TAICHUNG TAIWAN CHINA MED COLL HOSP,PEDIAT RES LAB TAICHUNG TAIWAN NATL CHENG KUNG UNIV HOSP TAINAN TAIWAN
Titolo Testata:
Acta paediatrica
fascicolo: 12, volume: 85, anno: 1996,
pagine: 1487 - 1490
SICI:
0803-5253(1996)85:12<1487:CEIPWE>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRONCHOPULMONARY DYSPLASIA; CONTROLLED TRIAL; 3-METHYLHISTIDINE; THERAPY;
Keywords:
BRONCHOPULMONARY DYSPLASIA; AMINO ACIDS; DEXAMETHASONE; 3-METHYLHISTIDINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
F.J. Tsai et al., "CATABOLIC EFFECT IN PREMATURE-INFANTS WITH EARLY DEXAMETHASONE TREATMENT", Acta paediatrica, 85(12), 1996, pp. 1487-1490

Abstract

To evaluate the catabolic effects of dexamethasone therapy on proteinmetabolism, amino acid concentrations and urinary 3-methylhistidine (3MH) were measured in 28 premature infants who were included in a double-blind controlled study using early dexamethasone therapy in the prevention of bronchopulmonary dysplasia. Fifteen infants received dexamethasone (0.5 mg/kg/day i.v.) and 13 infants received normal saline as control. Heparinized venous blood samples for amino acid analysis wereobtained before the study and again at day 5 after starting the study. Urinary 3MH was measured on days 1, 3, 5, 7, 14, 21, and 28 of treatment. A substantial increase in amino acid concentrations was observedin infants receiving dexamethasone. Alanine, glutamine, citrulline, ornithine and cystine concentrations increased twofold or more. The 3MH:creatinine ratio was increased in the treated group. These metabolic effects were most likely due to an increase in protein catabolism.

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Documento generato il 08/07/20 alle ore 06:56:39