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Titolo:
EFFECT OF DEFEROXAMINE AND SYMPATHECTOMY ON VASOSPASM FOLLOWING SUBARACHNOID HEMORRHAGE
Autore:
UTKAN T; SARIOGLU Y; KAYA T; AKGUN M; GOKSEL M; SOLAK O;
Indirizzi:
CUMHURIYET UNIV,SCH MED,DEPT PHARMACOL TR-58140 SIVAS TURKEY CUMHURIYET UNIV,SCH MED,DEPT NEUROSURG TR-58140 SIVAS TURKEY CUMHURIYET UNIV,SCH MED,DEPT RADIOL TR-58140 SIVAS TURKEY
Titolo Testata:
Pharmacology
fascicolo: 6, volume: 52, anno: 1996,
pagine: 353 - 361
SICI:
0031-7012(1996)52:6<353:EODASO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANINE BASILAR ARTERY; EXPERIMENTAL CEREBRAL VASOSPASM; RABBIT EAR ARTERY; ADRENERGIC-INNERVATION; CEREBROSPINAL-FLUID; SMOOTH-MUSCLE; ENDOTHELIUM; REACTIVITY; SEROTONIN; RECEPTORS;
Keywords:
DEFEROXAMINE; SYMPATHECTOMY; SUBARACHNOID HEMORRHAGE; VASCULAR SMOOTH MUSCLE; RABBIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
T. Utkan et al., "EFFECT OF DEFEROXAMINE AND SYMPATHECTOMY ON VASOSPASM FOLLOWING SUBARACHNOID HEMORRHAGE", Pharmacology, 52(6), 1996, pp. 353-361

Abstract

We examined the effects of subarachnoid hemorrhage (SAH) and treatment with deferoxamine (DFO) or sympathectomy on vascular smooth muscle function, as well as the underlying mechanisms involved, by recording the responses to noradrenaline and serotonin in isolated carotid arteries in vitro, All studies were performed before and 7 days after SAH. An experimental subarachnoid hemorrhage model was created in rabbits byinjecting autologous arterial blood into the subarachnoid space of the rabbits via cisterna magna punction. During the chronic stage of vasospasm following SAH deferoxamine (DFO) was given to the animals and cervical and periarterial sympathectomy was performed in the other groups of animals. In isolated carotid arteries noradrenaline (10(-8) to 10(-4) mol/l) and serotonin (10(-8) to 10(-4) mol/l) produced concentration-dependent contractions. These contractile responses were significantly enhanced in animals 7 days after SAH compared to controls and did not return to control values in carotid arteries obtained from animals treated with DFO or sympathectomy for 7 days after SAH. These results show that SAH causes supersensitivity in the carotid as well as cerebral arteries during the first week after SAH and could contribute tothe development of cerebral vasospasm. Both treatment with DFO and sympathectomy after SAH did not reduce the contractile responses to noradrenaline and serotonin in the carotid arteries. In conclusion, treatment with DFO or sympathectomy during the chronic stage of vasospasm after SAH did not affect the vascular responses of the extradural part of the carotid artery to vasoactive substances.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:28:46