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Titolo:
HIV-1 D-SUBTYPE VIRUSES IN FINLAND
Autore:
LAUKKANEN T; LIITSOLA K; SALMINEN M; LEINIKKI P;
Indirizzi:
NATL PUBL HLTH INST,DEPT INFECT DIS EPIDEMIOL,HIV LAB,MANNERHEIMINTIE166 SF-00300 HELSINKI FINLAND
Titolo Testata:
Clinical and diagnostic virology
fascicolo: 2-3, volume: 5, anno: 1996,
pagine: 205 - 210
SICI:
0928-0197(1996)5:2-3<205:HDVIF>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; PHYLOGENETIC ANALYSIS; SEQUENCES; TYPE-1; STRAIN; BRAIN;
Keywords:
CEREBROSPINAL FLUID (CSF); D CLUSTER; D SUBTYPE; PHYLOGENETIC ANALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
T. Laukkanen et al., "HIV-1 D-SUBTYPE VIRUSES IN FINLAND", Clinical and diagnostic virology, 5(2-3), 1996, pp. 205-210

Abstract

Background: Human immunodeficiency virus (HIV)-1 strains are divided into seven genetic subtypes based on their gag sequences (A, B, C, D, F, G and H). Strains that have appeared in Finland show unusual heterogeneity compared to most industrialized countries, up to 25% of the strains belong to non-B subtypes (Liitsola et al., 1996). Three D subtype viruses have so far been identified in Finland. All patients were men, one Kenyan immigrant and two Finnish men, who had been infected in Africa. Here we describe some of the characteristics of the genomic diversity of these strains. Method: The genotype was determined by direct solid-phase sequencing of the p7 gag region. Phylogenetic analysis was done using standard methods. Results: The analysis showed that the D subtype sequences clustered clearly distinctly from the other non-B strains, but did not suggest any transmission links between the three cases. From one case both cerebrospinal fluid (CSF) and blood leukocyte virus isolates were studied. The analysis revealed significant differences between the blood and CSF viruses. A four amino acid duplication and other differences were observed between the strains. Conclusion:The results confirm that D subtype viruses do indeed occur in Finlandand they represent quite heterogenic strains within the D cluster.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/02/20 alle ore 17:58:26