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Titolo:
100 CONSECUTIVE THYMECTOMIES FOR MYASTHENIA-GRAVIS
Autore:
DETTERBECK FC; SCOTT WW; HOWARD JF; EGAN TM; KEAGY BA; STAREK PJK; MILL MR; WILCOX BR;
Indirizzi:
UNIV N CAROLINA,SCH MED,DEPT SURG,DIV CARDIOTHORAC SURG,108 BURNETT WOMACK BLDG,CB 7065 CHAPEL HILL NC 27514 UNIV N CAROLINA,SCH MED,DEPT NEUROL CHAPEL HILL NC 27514
Titolo Testata:
The Annals of thoracic surgery
fascicolo: 1, volume: 62, anno: 1996,
pagine: 242 - 245
SICI:
0003-4975(1996)62:1<242:1CTFM>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSSTERNAL THYMECTOMY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
F.C. Detterbeck et al., "100 CONSECUTIVE THYMECTOMIES FOR MYASTHENIA-GRAVIS", The Annals of thoracic surgery, 62(1), 1996, pp. 242-245

Abstract

Background. Between June 1977 and November 1993, 100 consecutive thymectomies for myasthenia gravis were performed at University of North Carolina Hospitals in Chapel Hill. Methods. A consistent, planned protocol involving preoperative, intraoperative, and postoperative care wasfollowed. All thymectomies were performed through a median sternotomywith removal of all visible thymus and perithymic fat in the anteriormediastinum. Results. There was no perioperative mortality or long-term morbidity. Mean postoperative hospital stay was 6.3 days (range, 3 to 18 days). Ninety-six percent of the patients were extubated the dayof the operation, and all patients were extubated within 24 hours. Mean postoperative intensive care unit stay was 1.2 days (range, 1 to 4 days). After a mean follow-up of 65 months (range, 1 to 199 months), 78% of all patients are improved by at least one modified Osserman classification when their current status is compared with their worst preoperative disease severity. In fact, 69% of patients with mild disease preoperatively (class I, II, or III maximal severity) are in pharmacologic remission (asymptomatic without regular medication), whereas 29% of patients with severe disease (class IV or V) are in remission (p = 0.0001). Conclusions. Our programmatic approach to thymectomy through a sternotomy has shown minimal morbidity and mortality, It is beneficial to myasthenics at both ends of the age and severity spectrum.

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Documento generato il 02/12/20 alle ore 17:46:03