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Titolo:
EPIDEMIOLOGIC AND MOLECULAR CHARACTERISTICS OF HIV-INFECTION IN GABON, 1986-1994
Autore:
DELAPORTE E; JANSSENS W; PEETERS M; BUVE A; DIBANGA G; PERRET JL; DITSAMBOU V; MBA JR; COURBOT MCG; GEORGES A; BOURGEOIS A; SAMB B; HENZEL D; HEYNDRICKX L; FRANSEN K; VANDERGROEN G; LAROUZE B;
Indirizzi:
ORSTOM,RETROVIRUS LAB,AIDS PROGRAMME,INST FRANCAIS RECH SCI DEV,911 AVE AGROPOLIS F-34000 MONTPELLIER FRANCE INST TROP MED,DEPT INFECT & IMMUN B-2000 ANTWERP BELGIUM NATL AIDS PROGRAMME LIBREVILLE GABON GEN HOSP LIBREVILLE GABON NATL LAB LIBREVILLE GABON BLOOD BANK LIBREVILLE GABON INT RES CTR FRANCEVILLE GABON BICHAT CLAUDE BERNARD CENT HOSP,INSERM,U13,INST MED & EPIDEMIOL AFRICAINES PARIS FRANCE
Titolo Testata:
AIDS
fascicolo: 8, volume: 10, anno: 1996,
pagine: 903 - 910
SICI:
0269-9370(1996)10:8<903:EAMCOH>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIBODIES; AFRICA; VIRUS; TRANSMISSION;
Keywords:
HIV; AFRICA; PREVALENCE; VARIABILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
E. Delaporte et al., "EPIDEMIOLOGIC AND MOLECULAR CHARACTERISTICS OF HIV-INFECTION IN GABON, 1986-1994", AIDS, 10(8), 1996, pp. 903-910

Abstract

Objective: To describe trends in the prevalence of HIV-1 infection indifferent populations in Gabon, and the molecular characteristics of circulating HIV strains. Methods: Data were collected on HIV prevalence through sentinel surveillance surveys in different populations in Libreville (the capital) and in Franceville. In Libreville, a total of 7082 individuals (hospitalized patients, tuberculosis patients, pregnant women, asymptomatic adults, prisoners) were recruited between 1986 and 1994. In Franceville, we tested 771 pregnant women and 886 healthy asymptomatic adults (1986-1988). Sera were screened for HIV antibodiesby enzyme-linked immunosorbent assay (ELISA) and confirmed by Westernblot or line immunoassay (LIA). Reactive samples in ELISA were testedfor the presence of antibodies to HIV-1 group O viruses by ELISA using V3 peptides from HIV-1(ANT-70) and HIV-1(MVP-5180) followed by confirmation by LIA and a specific Western blot. Seventeen HIV-1 strains were isolated (1988-1993) and a 900 base-pair fragment encoding the env region containing V3, V4, V5 and beginning of gp41 was sequenced and aphylogenetic tree was constructed. Results: HIV prevalence was relatively low and remained stable (0.7-1.6% in pregnant women, 2.7-2.2% in the general population). The prevalence was also stable among prisoners (2.1-2.6%). Among hospitalized and tuberculosis patients prevalence was higher and increased (1.8-12.7% and 1.5-16.2%, respectively). On ly three sera had antibodies to HIV-1 group O. The 17 HIV-1 strains represent six different genetic subtypes including type O. Conclusion: Our data from 1986 to 1994 show a stable and low HIV prevalence in Gabon, and a high genetic diversity of HIV-1 strains. This, also observed in Cameroon, is in contrast to that found elsewhere in Africa. Differences in rate of spread of HIV infection are probably explained by interplay between numerous factors. The role of different HIV subtypes in the dynamics of the HIV epidemic should be examined further.

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Documento generato il 04/12/20 alle ore 01:11:46