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Titolo:
RELATIONSHIP BETWEEN MEMBRANE-POTENTIAL AND RESPIRATION RATE IN ISOLATED LIVER-MITOCHONDRIA FROM RATS FED AN ENERGY DENSE DIET
Autore:
LIONETTI L; IOSSA S; BRAND MD; LIVERINI G;
Indirizzi:
UNIV NAPLES,DIPARTIMENTO FISIOL GEN & AMBIENTALE,VIA MEZZOCANNONE 8 I-80134 NAPLES ITALY UNIV NAPLES,DIPARTIMENTO FISIOL GEN & AMBIENTALE I-80134 NAPLES ITALY UNIV CAMBRIDGE,DEPT BIOCHEM CAMBRIDGE CB2 1QW ENGLAND
Titolo Testata:
Molecular and cellular biochemistry
fascicolo: 2, volume: 158, anno: 1996,
pagine: 133 - 138
SICI:
0300-8177(1996)158:2<133:RBMARR>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXIDATIVE-PHOSPHORYLATION; INDUCED THERMOGENESIS; HEPATIC MITOCHONDRIAL; INNER MEMBRANE; FAT; STARVATION; TRANSPORT; BALANCE; FORCE; LEAK;
Keywords:
MITOCHONDRIA; OXYGEN CONSUMPTION; TOP-DOWN ELASTICITY ANALYSIS; ENERGY DENSE DIET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
L. Lionetti et al., "RELATIONSHIP BETWEEN MEMBRANE-POTENTIAL AND RESPIRATION RATE IN ISOLATED LIVER-MITOCHONDRIA FROM RATS FED AN ENERGY DENSE DIET", Molecular and cellular biochemistry, 158(2), 1996, pp. 133-138

Abstract

We studied the relationship between membrane potential and respiration rate in isolated liver mitochondria from rats fed an energy dense diet. We conceptually divided the system into blocks of reactions that produced or consumed mitochondrial membrane potential and then measuredthe kinetic response of these blocks of reactions to this potential using NAD-linked and FAD-linked substrates. We show that decreased respiration rate with an NAD-linked substrate is accounted for by decreased kinetic response of the substrate oxidation pathway to the potential. No variation in the kinetic response of the above blocks of reactions to the potential was found using an FAD-linked substrate. These results indicate that FAD-linked and NAD-linked pathways are differently affected in rats fed an energy dense diet.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 03:24:59