Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PHENOTYPIC CHARACTERIZATION OF THE TRP64ARG POLYMORPHISM IN THE BETA(3)-ADRENERGIC RECEPTOR GENE IN NORMAL-WEIGHT AND OBESE SUBJECTS
Autore:
LI LS; LONNQVIST F; LUTHMAN H; ARNER P;
Indirizzi:
HUDDINGE HOSP,KAROLINSKA INST,DEPT MED,MK DIV,M61 S-14186 HUDDINGE SWEDEN HUDDINGE HOSP,KAROLINSKA INST,DEPT MED,MK DIV S-14186 HUDDINGE SWEDEN HUDDINGE HOSP,RES CTR S-14186 HUDDINGE SWEDEN KAROLINSKA INST,KAROLINSKA HOSP,DEPT MOLEC MED S-10401 STOCKHOLM SWEDEN
Titolo Testata:
Diabetologia
fascicolo: 7, volume: 39, anno: 1996,
pagine: 857 - 860
SICI:
0012-186X(1996)39:7<857:PCOTTP>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Keywords:
INSULIN; CATECHOLAMINES; LIPOLYSIS; FAT CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
L.S. Li et al., "PHENOTYPIC CHARACTERIZATION OF THE TRP64ARG POLYMORPHISM IN THE BETA(3)-ADRENERGIC RECEPTOR GENE IN NORMAL-WEIGHT AND OBESE SUBJECTS", Diabetologia, 39(7), 1996, pp. 857-860

Abstract

The beta(3)-adrenergic receptor, located mainly in fat cells of visceral adipose tissue, is involved in the regulation of lipolysis and thermogenesis. Recently, a mutation in the corresponding gene resulting in the replacement of tryptophan by arginine in position 64 (Trp64Arg) has been demonstrated, which associated with obesity and metabolic complications of obesity. We have investigated whether this polymorphism is associated with changes in beta(3)-adrenergic receptor function or clinical characteristics in 40 non-obese and 43 obese non-diabetic subjects who underwent elective abdominal surgery. The beta-adrenergic receptor gene polymorphism was examined by restriction-enzyme cleavage conformation. Beta(3)-adrenergic receptor function was investigated by measuring lipolysis in isolated visceral white fat cells incubated with noradrenaline (natural ligand) or (CGP) 12177 (selective beta(3)-agonist). No homozygotes for the mutation were found. The allelic frequency of Trp64Arg was similar in obese and non-obese subjects (9.4 and 12.5 %, respectively). In obese and non-obese subjects there was no change in body mass index, body fat distribution, fat cell size, fasting circulating levels of insulin, glucose or lipids, blood pressure or adipocyte lipolysis induced by noradrenaline or CGP 12177 when Trp64Arg heterozygotes were compared with Trp64 homozygotes. Our results suggestthat the Trp64Arg mutation in its heterozygous form is not a major determinant of beta(3)-adrenergic receptor function (when assessed by lipolysis in white adipose tissue) or of the pathophysiology of obesity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:33:42