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Titolo:
INTERACTION OF CD31 WITH A HETEROPHILIC COUNTERRECEPTOR INVOLVED IN DOWN-REGULATION OF HUMAN T-CELL RESPONSES
Autore:
PRAGER E; SUNDERPLASSMANN R; HANSMANN C; KOCH C; HOLTER W; KNAPP W; STOCKINGER H;
Indirizzi:
UNIV VIENNA,INST IMMUNOL,SANDOZ FORSCH INST,VIRCC,BRUNNERSTR 59 A-1235 VIENNA AUSTRIA UNIV VIENNA,INST IMMUNOL,SANDOZ FORSCH INST,VIRCC A-1235 VIENNA AUSTRIA
Titolo Testata:
The Journal of experimental medicine
fascicolo: 1, volume: 184, anno: 1996,
pagine: 41 - 50
SICI:
0022-1007(1996)184:1<41:IOCWAH>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADHESION MOLECULE; TRANSENDOTHELIAL MIGRATION; DOWN-REGULATION; PECAM-1; ACTIVATION; SUPERFAMILY; EXPRESSION; PHENOTYPES; CLONING; ANTIGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
E. Prager et al., "INTERACTION OF CD31 WITH A HETEROPHILIC COUNTERRECEPTOR INVOLVED IN DOWN-REGULATION OF HUMAN T-CELL RESPONSES", The Journal of experimental medicine, 184(1), 1996, pp. 41-50

Abstract

CD31 is a 130-kD glycoprotein of the immunoglobulin (Ig) superfamily expressed on the surface of endothelial cells, platelets, and several leukocyte subsets. Previous reports indicated that CD31 can mediate intercellular adhesion via both homophilic and heterophilic interaction mechanisms. Using a soluble recombinant CD31-Ig fusion protein (CD33 receptor globulin [Rg]), we demonstrate here that human CD31(-) T lymphocytes and CD4(+)CD31(-) T cell clones express a heterophilic CD31 ligand that is upregulated 18 h after activation. interaction of CD31Rg with CD31(-) T helper cell (Th) clones was divalent cation independent but could be blocked by heparin, thus indicating that the CD31 counterreceptor on T cells can be distinguished from the ligands identified on other cell types. Moreover, a single chain protein of 120 kD was precipitated by CD31Rg from the lysates of CD31(-) Th clones. CD31Rg completely downregulated the proliferative response and cytokine production (interleukin-4, interferon-gamma, and tumor necrosis factor-alpha) of CD31(-) Th clones when the cells were maximally stimulated via immobilized CD3 monoclonal antibody. These results suggest that interactionof CD31 with a heterophilic counterreceptor on T lymphocytes can interfere with a positive regulatory pathway of T cell activation, or directly signal T cells to downregulate immune function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 04:20:23