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Titolo:
4 DISTINCT MEMBRANE-BOUND DIPEPTIDASE RNAS ARE DIFFERENTIALLY EXPRESSED AND SHOW DISCORDANT REGULATION WITH GAMMA-GLUTAMYL-TRANSPEPTIDASE
Autore:
HABIB GM; BARRIOS R; SHI ZZ; LIEBERMAN MW;
Indirizzi:
BAYLOR COLL MED,DEPT PATHOL,1 BAYLOR PLAZA HOUSTON TX 77030 BAYLOR COLL MED,DEPT PATHOL HOUSTON TX 77030 BAYLOR COLL MED,DEPT CELL BIOL HOUSTON TX 77030
Titolo Testata:
The Journal of biological chemistry
fascicolo: 27, volume: 271, anno: 1996,
pagine: 16273 - 16280
SICI:
0021-9258(1996)271:27<16273:4DMDRA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN RENAL DIPEPTIDASE; TRANSFERASE TRANSPEPTIDASE; DEHYDROPEPTIDASE-I; MOLECULAR-CLONING; GLUTATHIONE; TRANSPORT; STEP; CDNA; DNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
G.M. Habib et al., "4 DISTINCT MEMBRANE-BOUND DIPEPTIDASE RNAS ARE DIFFERENTIALLY EXPRESSED AND SHOW DISCORDANT REGULATION WITH GAMMA-GLUTAMYL-TRANSPEPTIDASE", The Journal of biological chemistry, 271(27), 1996, pp. 16273-16280

Abstract

Membrane-bound dipeptidase (MBD) participates in the degradation of glutathione by cleaving the cysteinylglycine bond of cystinyl bisglycine (oxidized cysteinylglycine) following removal of a gamma-glutamyl group by gamma-glutamyl transpeptidase (GGT). In the mouse, MBD RNA is most abundant in small intestine, kidney, and lung and is represented by four distinct RNA species, These are generated by transcription fromtwo promoters located 6 kilobases apart in the 5' flanking region of the gene and by the use of two different poly(A) addition sites, Promoter I is used primarily in small intestine and kidney, whereas promoter II is most active in lung and kidney, We found a discordance in the expected co-expression of MBD and GGT; as expected, MBD and GGT are both expressed at high levels in the kidney and small intestine, However, in the lung, MBD is expressed at high levels, whereas GGT is almost undetectable, The reverse is true in the seminal vesicles and fetal liver. Thus, although both enzymes may function in concert to metabolizeglutathione in kidney and small intestine, in other tissues they appear to act independently, suggesting that they have independent roles in other biological processes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 23:19:57