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Titolo:
DOES THE CLASSIFICATION-SYSTEM FIT DISEASE PROGRESSION IN PERINATAL HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION
Autore:
DEMARTINO M; ZAPPA M; GALLI L; ROSSI ME; VIERUCCI A;
Indirizzi:
UNIV FLORENCE,DEPT PAEDIAT,VIA LUCA GIORDANO 13 I-50132 FLORENCE ITALY CTR STUDY & PREVENT CANC,EPIDEMIOL UNIT FLORENCE ITALY
Titolo Testata:
Acta paediatrica
fascicolo: 6, volume: 85, anno: 1996,
pagine: 724 - 727
SICI:
0803-5253(1996)85:6<724:DTCFDP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIV-1 INFECTION; CHILDREN; INFANTS; RISK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
M. Demartino et al., "DOES THE CLASSIFICATION-SYSTEM FIT DISEASE PROGRESSION IN PERINATAL HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION", Acta paediatrica, 85(6), 1996, pp. 724-727

Abstract

The objective was to test the applicability of the new classificationfor paediatric human immonodeficiency virus infection. The person-time of each state, transition probabilities and survival (+/- standard errors) at 5 years, and median sojourn-time were calculated on 39 perinatally infected children followed up from the first month of life for a median of 64.5 (1.2- 120.1) months. The person-times of the N2, N3, B1, C1, and C2 states were low. The transition probabilities and sojourn-times were similar for A (48.1 +/- 10.8%; 63.5 months), B (50.5 +/-15.5%; 44.9 months) and C (74.6 +/- 15.1%; 43.1 months) clinical categories, which differed (p < 0.025) from the N category (87.9 +/- 5.5%;12.05 months). The survival probabilities after 5 years of entering the A, B and C categories were 84.8 +/- 10.7%, 60.5 +/- 19.8% and 14.8 /- 13.5%, respectively (p < 0.001). Immunological category 3 had lower transition probabilities and longer sojourn-times (58.8 +/- 16.6%; 53.3 months) than categories 1 (71.3 +/- 8.1%; 33.2 months) and 2 (75.6+/- 10.5%; 19.8 months) (p < 0.01). The transition probabilities to C3 for states N3, A3 or B3 were 52.5 +/- 13.5%, In conclusion, the classification fits the clinical history better than the immunological history.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 09:28:34